LOCUS       CP001510               20636 bp    DNA              UNK 01-JAN-1980
DEFINITION  Methylobacterium extorquens AM1, complete genome.
ACCESSION   CP001510
VERSION     CP001510.1
KEYWORDS    .
SOURCE      .
  ORGANISM  .
            .
FEATURES             Location/Qualifiers
     cluster         1..20636
                     /note="Cluster number: 6"
                     /note="Detection rule(s) for this cluster type:
                     hserlactone: (Autoind_synth);"
                     /clusterblast="2. FP103042_c7	Methylobacterium extorquens
                     DM4 str. DM4 chromosome, complete ... (45% of genes show
                     similarity)"
                     /clusterblast="3. CP000908_c7	Methylobacterium extorquens
                     PA1, complete genome. (45% of genes show similarity)"
                     /clusterblast="4. CP001298_c7	Methylobacterium extorquens
                     CM4, complete genome. (45% of genes show similarity)"
                     /clusterblast="5. CP001029_c7	Methylobacterium populi
                     BJ001, complete genome. (41% of genes show similarity)"
                     /clusterblast="6. AGJK01000059_c1	Methylobacterium
                     extorquens DSM 13060 ctg1081, whole genom... (32% of genes
                     show similarity)"
                     /clusterblast="7. CP000250_c4	Rhodopseudomonas palustris
                     HaA2, complete genome. (9% of genes show similarity)"
                     /clusterblast="8. CP001349_c7	Methylobacterium nodulans ORS
                     2060, complete genome. (12% of genes show similarity)"
                     /clusterblast="9. CCAZ020000003_c1	Afipia felis genospecies
                     A WGS project CCAZ000000000 data... (9% of genes show
                     similarity)"
                     /clusterblast="10. CP001349_c3	Methylobacterium nodulans
                     ORS 2060, complete genome. (6% of genes show similarity)"
                     /clusterblast="11. CP000943_c12	Methylobacterium sp. 4-46,
                     complete genome. (6% of genes show similarity)"
                     /product="hserlactone"
     gene            complement(552..1424)
                     /locus_tag="MexAM1_META1p4954"
     CDS             complement(552..1424)
                     /locus_tag="MexAM1_META1p4954"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="conserved hypothetical protein"
                     /transl_table=11
                     /note="Evidence 4 : Homologs of previously reported genes
                     of unknown function"
                     /db_xref="GI:240011335"
                     /translation="MPGYLPFAGALKLPAYTCDNCGFWQRHFEAPPHCPMCLDARHVVP
                     QDGWRFRTTREAQDAFPCHWEELEPGIWRFWNDPVSGIGPSAYLIRTENGNMGFEACPV
                     FSEAALDQIERLGGMQVLSASHPHSYGALVQLQDRFDPELCLPAADFIWSAALQVSWPY
                     DDFLEPLPGLELHRTAGHFDGHAVLFDRKRKICFCGDALKFELDPNDFRKALTISAHKA
                     FVRGVPLTVNELRRYRDVFERLDFTQTWTPFEPAANVGRAEVVALIDAMLGSRPHAAPV
                     PLDHLRRST"
                     /protein_id="ACS42561.1"
     PFAM_domain     complement(789..1049)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4954"
                     /description="Metallo-beta-lactamase superfamily"
                     /database="Pfam-A.hmm"
                     /evalue="6.70E-04"
                     /domain="Lactamase_B"
                     /asDomain_id="fullhmmer_MexAM1_META1p4954_0001"
                     /note="Pfam-A.hmm-Hit: Lactamase_B. Score: 19.3. E-value:
                     0.00067. Domain range: 52..157."
                     /db_xref="PFAM: PF00753"
                     /score="19.3"
                     /aSTool="fullhmmer"
                     /translation="HPHSYGALVQLQDRFDPELCLPAADFIWSAALQVSWPYDDFLEPL
                     PGLELHRTAGHFDGHAVLFDRKRKICFCGDALKFELDPNDFR"
                     /label="MexAM1_META1p4954"
     gene            complement(1609..2604)
                     /locus_tag="MexAM1_META1p4955"
     CDS             complement(1609..2604)
                     /locus_tag="MexAM1_META1p4955"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="Short-chain dehydrogenase/reductase SDR"
                     /transl_table=11
                     /note="Evidence 2b : Function of strongly homologous gene;
                     Product type e : enzyme"
                     /note="smCOG:
                     SMCOG1001:short-chain_dehydrogenase/reductase_SDR (Score:
                     161.6; E-value: 4e-49);"
                     /db_xref="GI:240011336"
                     /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein"
                     /sec_met="NRPS/PKS Domain: PKS_KR (0-163). E-value:
                     2.6e-16. Score: 51.6; Predicted KR activity: inactive;
                     Predicted KR stereochemistry: C2;"
                     /translation="MVTGGSAGIGLATAQLFAQRGWSVAILARGAERLAEAEALLAREG
                     GRVLAIPADVADAAAVEAAADRIEQELGPIRAWINNAMTTIVSPADQVTPEEYRTVTGA
                     TYLGTVHGTLSALHRMKPRDRGVIVQVSSGLAIRAAPLQAPYCAAKFAISGFTDSLRAE
                     LIHENSKIALSVVYLPAVNTPQFGWTRTRTGHGQRAPDPVFDPRLCAEAIHHAAERPTR
                     EVWVGRTSVLMAAAQALLPSYADRKAAQSWDDMVEDKAVPDRRGNLDAPAPGAARIDGA
                     ISERAKTTRSEFWTSRERDALVLGAVGAALLGTALAARALRRPLRLLGRL"
                     /protein_id="ACS42562.1"
     PFAM_domain     complement(2092..2586)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4955"
                     /description="Enoyl-(Acyl carrier protein) reductase"
                     /database="Pfam-A.hmm"
                     /evalue="5.30E-05"
                     /domain="adh_short_C2"
                     /asDomain_id="fullhmmer_MexAM1_META1p4955_0003"
                     /note="Pfam-A.hmm-Hit: adh_short_C2. Score: 23.1. E-value:
                     5.3e-05. Domain range: 5..171."
                     /score="23.1"
                     /aSTool="fullhmmer"
                     /translation="AGIGLATAQLFAQRGWSVAILARGAERLAEAEALLAREGGRVLAI
                     PADVADAAAVEAAADRIEQELGPIRAWINNAMTTIVSPADQVTPEEYRTVTGATYLGTV
                     HGTLSALHRMKPRDRGVIVQVSSGLAIRAAPLQAPYCAAKFAISGFTDSLRAELIHENS
                     KI"
                     /label="MexAM1_META1p4955"
     PFAM_domain     complement(2107..2604)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4955"
                     /description="KR domain"
                     /database="Pfam-A.hmm"
                     /evalue="1.20E-18"
                     /domain="KR"
                     /asDomain_id="fullhmmer_MexAM1_META1p4955_0002"
                     /note="Pfam-A.hmm-Hit: KR. Score: 67.4. E-value: 1.2e-18.
                     Domain range: 3..169."
                     /db_xref="PFAM: PF08659"
                     /score="67.4"
                     /aSTool="fullhmmer"
                     /translation="VVTGGSAGIGLATAQLFAQRGWSVAILARGAERLAEAEALLAREG
                     GRVLAIPADVADAAAVEAAADRIEQELGPIRAWINNAMTTIVSPADQVTPEEYRTVTGA
                     TYLGTVHGTLSALHRMKPRDRGVIVQVSSGLAIRAAPLQAPYCAAKFAISGFTDSLRAE
                     LIH"
                     /label="MexAM1_META1p4955"
     PFAM_domain     complement(2113..2601)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4955"
                     /description="short chain dehydrogenase"
                     /database="Pfam-A.hmm"
                     /evalue="4.30E-32"
                     /domain="adh_short"
                     /asDomain_id="fullhmmer_MexAM1_META1p4955_0001"
                     /note="Pfam-A.hmm-Hit: adh_short. Score: 111.3. E-value:
                     4.3e-32. Domain range: 4..166."
                     /db_xref="PFAM: PF00106"
                     /score="111.3"
                     /aSTool="fullhmmer"
                     /translation="VTGGSAGIGLATAQLFAQRGWSVAILARGAERLAEAEALLAREGG
                     RVLAIPADVADAAAVEAAADRIEQELGPIRAWINNAMTTIVSPADQVTPEEYRTVTGAT
                     YLGTVHGTLSALHRMKPRDRGVIVQVSSGLAIRAAPLQAPYCAAKFAISGFTDSLRAEL
                     "
                     /label="MexAM1_META1p4955"
     aSDomain        complement(2116..2604)
                     /domain="PKS_KR"
                     /database="nrpspksdomains.hmm"
                     /evalue="2.60E-16"
                     /locus_tag="MexAM1_META1p4955"
                     /label="MexAM1_META1p4955_KR1"
                     /detection="hmmscan"
                     /score="51.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /translation="VVTGGSAGIGLATAQLFAQRGWSVAILARGAERLAEAEALLAREG
                     GRVLAIPADVADAAAVEAAADRIEQELGPIRAWINNAMTTIVSPADQVTPEEYRTVTGA
                     TYLGTVHGTLSALHRMKPRDRGVIVQVSSGLAIRAAPLQAPYCAAKFAISGFTDSLRAE
                     "
                     /asDomain_id="nrpspksdomains_MexAM1_META1p4955_KR1"
     CDS_motif       complement(2500..2601)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4955"
                     /motif="PKSI-KR_m1"
                     /database="abmotifs"
                     /evalue="1.04E-02"
                     /asDomain_id="nrpspksmotif_MexAM1_META1p4955_0001"
                     /note="NRPS/PKS Motif: PKSI-KR_m1 (e-value: 0.01036,
                     bit-score: 10.7)"
                     /score="10.7"
                     /aSTool="pksnrpsmotif"
                     /translation="VTGGSAGIGLATAQLFAQRGWSVAILARGAERLA"
                     /label="PKSI-KR_m1"
     gene            complement(2810..6019)
                     /locus_tag="MexAM1_META1p4956"
                     /gene="acrF"
     CDS             complement(2810..6019)
                     /function="4.2.A.6 : The Resistance-Nodulation-Cell
                     Division (RND) Superfamily"
                     /function="5.6.4 : Drug resistance/sensitivity"
                     /function="6.1 : Membrane"
                     /function="7.3 : Inner membrane"
                     /locus_tag="MexAM1_META1p4956"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="multidrug transport protein, acriflavin
                     resistance protein F (RND family)"
                     /transl_table=11
                     /note="Evidence 2b : Function of strongly homologous gene;
                     Product type t : transporter"
                     /note="smCOG: SMCOG1049:AcrB/AcrD/AcrF_family_protein
                     (Score: 1155.1; E-value: 0.0);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4956.png"
                     /db_xref="GI:240011337"
                     /translation="MRFAHFFVDRPIFASVTSIIFLIVGFVAYEKLPVSQYPEIVPPTV
                     TVRASFPGANAETVAATIATPLEQEINGVDNMLYMTSLSTNDGAMLLTVTFKVGTNLDI
                     ANVLVQNRLSVAQPRLPPDVRNLGVTVRKASPDLMLVVHLLSPKRTYDQNYLANYIYLN
                     IRDELLRLDGVGDISIFGGNEYAERVWIDPQKMAAYGLTTTDVTSALQEQNVQVAAGQL
                     NGPPAAPGAAFQLVVQSQGRFQSPEQFADVIVKANDGRLVRVRDIARVEMGQKDYTTNS
                     FLNDTPAVGIGAFQRPGTNALEAAESVKATMEQLKKNFPPDVEYRIAYNPTEFIEESIH
                     EVYKTLFEAVLLVVIVVLVFLQSWRTALIPVIAIPVSLVGTFAVMSALGFSLNNLTLFG
                     LVLAIGIVVDDAIVVVENVERNMAEGLSAGEAAHKTMDEVGGAVIAIALVLAAVFIPTA
                     FIPGISGQFYKQFALTIAASTIISAFNSLTLSPALCKLLLKPHHEHKPPKFFLTRFLNW
                     LAHLFNRGFDALSNGYAHSIRFLTGTAIGVIAMLILYAGVIAGTLHLARTTPTGFIPDQ
                     DQGYLIGVVQLPAGSSLDRTTDAVNRAAKIARGVDGITNTVIIAGFDGATFTNTTNAAV
                     MFLTLKGAKERAAQGRSAAVITGDVLKATAGIQEARIIVIPPPPVRGLGQGGGFKMQIE
                     SRQSSEIGPLLAAAGEVIGQANQSKDVTRVFTTFGNDTPQLYLDIDRTIARMLNVPLAN
                     VFSTVQTALGGAYVNDFNTLGRIYQVRVQGDAVYRMSRRDIEQLKVRSSTGALVPMGTL
                     ASIRDIAGPQIVQRFNLYYSVPLQGVAQPGVSTGQALDTMEEIAKRALPEGYSYDWTEI
                     AFQQKAAGDTAIYVFALGVLLVFLVLAAQYESWALPLAILLVVPTGVLAALFGVQLRGQ
                     DNNILTQIGLIVLIGLAAKNAILIVEFAHDIENSENKGPVDAAVQACRLRLRPILMTAF
                     AFILGVLPLVIATGPGAEMRQALGTAVFFGMIGATFFGLFLTPVFYVVIRKAVIWIGRK
                     RGKDTHGGDGHGAPHGAPAHG"
                     /gene="acrF"
                     /protein_id="ACS42563.1"
     PFAM_domain     complement(2867..3394)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4956"
                     /description="MMPL family"
                     /database="Pfam-A.hmm"
                     /evalue="2.60E-05"
                     /domain="MMPL"
                     /asDomain_id="fullhmmer_MexAM1_META1p4956_0003"
                     /note="Pfam-A.hmm-Hit: MMPL. Score: 23.1. E-value: 2.6e-05.
                     Domain range: 138..314."
                     /db_xref="PFAM: PF03176"
                     /score="23.1"
                     /aSTool="fullhmmer"
                     /translation="KAAGDTAIYVFALGVLLVFLVLAAQYESWALPLAILLVVPTGVLA
                     ALFGVQLRGQDNNILTQIGLIVLIGLAAKNAILIVEFAHDIENSENKGPVDAAVQACRL
                     RLRPILMTAFAFILGVLPLVIATGPGAEMRQALGTAVFFGMIGATFFGLFLTPVFYVVI
                     RKAVIWIGRKRGK"
                     /label="MexAM1_META1p4956"
     PFAM_domain     complement(2903..6010)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4956"
                     /description="AcrB/AcrD/AcrF family"
                     /database="Pfam-A.hmm"
                     /evalue="0.00E+00"
                     /domain="ACR_tran"
                     /asDomain_id="fullhmmer_MexAM1_META1p4956_0001"
                     /note="Pfam-A.hmm-Hit: ACR_tran. Score: 1150.6. E-value:
                     0.0. Domain range: 1..1021."
                     /db_xref="PFAM: PF00873"
                     /score="1150.6"
                     /aSTool="fullhmmer"
                     /translation="AHFFVDRPIFASVTSIIFLIVGFVAYEKLPVSQYPEIVPPTVTVR
                     ASFPGANAETVAATIATPLEQEINGVDNMLYMTSLSTNDGAMLLTVTFKVGTNLDIANV
                     LVQNRLSVAQPRLPPDVRNLGVTVRKASPDLMLVVHLLSPKRTYDQNYLANYIYLNIRD
                     ELLRLDGVGDISIFGGNEYAERVWIDPQKMAAYGLTTTDVTSALQEQNVQVAAGQLNGP
                     PAAPGAAFQLVVQSQGRFQSPEQFADVIVKANDGRLVRVRDIARVEMGQKDYTTNSFLN
                     DTPAVGIGAFQRPGTNALEAAESVKATMEQLKKNFPPDVEYRIAYNPTEFIEESIHEVY
                     KTLFEAVLLVVIVVLVFLQSWRTALIPVIAIPVSLVGTFAVMSALGFSLNNLTLFGLVL
                     AIGIVVDDAIVVVENVERNMAEGLSAGEAAHKTMDEVGGAVIAIALVLAAVFIPTAFIP
                     GISGQFYKQFALTIAASTIISAFNSLTLSPALCKLLLKPHHEHKPPKFFLTRFLNWLAH
                     LFNRGFDALSNGYAHSIRFLTGTAIGVIAMLILYAGVIAGTLHLARTTPTGFIPDQDQG
                     YLIGVVQLPAGSSLDRTTDAVNRAAKIARGVDGITNTVIIAGFDGATFTNTTNAAVMFL
                     TLKGAKERAAQGRSAAVITGDVLKATAGIQEARIIVIPPPPVRGLGQGGGFKMQIESRQ
                     SSEIGPLLAAAGEVIGQANQSKDVTRVFTTFGNDTPQLYLDIDRTIARMLNVPLANVFS
                     TVQTALGGAYVNDFNTLGRIYQVRVQGDAVYRMSRRDIEQLKVRSSTGALVPMGTLASI
                     RDIAGPQIVQRFNLYYSVPLQGVAQPGVSTGQALDTMEEIAKRALPEGYSYDWTEIAFQ
                     QKAAGDTAIYVFALGVLLVFLVLAAQYESWALPLAILLVVPTGVLAALFGVQLRGQDNN
                     ILTQIGLIVLIGLAAKNAILIVEFAHDIENSENKGPVDAAVQACRLRLRPILMTAFAFI
                     LGVLPLVIATGPGAEMRQALGTAVFFGMIGATFFGLFLTPVFYVVIR"
                     /label="MexAM1_META1p4956"
     PFAM_domain     complement(4529..5002)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4956"
                     /description="MMPL family"
                     /database="Pfam-A.hmm"
                     /evalue="1.50E-14"
                     /domain="MMPL"
                     /asDomain_id="fullhmmer_MexAM1_META1p4956_0002"
                     /note="Pfam-A.hmm-Hit: MMPL. Score: 53.5. E-value: 1.5e-14.
                     Domain range: 142..302."
                     /db_xref="PFAM: PF03176"
                     /score="53.5"
                     /aSTool="fullhmmer"
                     /translation="HEVYKTLFEAVLLVVIVVLVFLQSWRTALIPVIAIPVSLVGTFAV
                     MSALGFSLNNLTLFGLVLAIGIVVDDAIVVVENVERNMAEGLSAGEAAHKTMDEVGGAV
                     IAIALVLAAVFIPTAFIPGISGQFYKQFALTIAASTIISAFNSLTLSPALCKLL"
                     /label="MexAM1_META1p4956"
     PFAM_domain     complement(4529..5008)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4956"
                     /description="Protein export membrane protein"
                     /database="Pfam-A.hmm"
                     /evalue="2.10E-08"
                     /domain="SecD_SecF"
                     /asDomain_id="fullhmmer_MexAM1_META1p4956_0004"
                     /note="Pfam-A.hmm-Hit: SecD_SecF. Score: 33.5. E-value:
                     2.1e-08. Domain range: 28..186."
                     /db_xref="PFAM: PF02355"
                     /score="33.5"
                     /aSTool="fullhmmer"
                     /translation="SIHEVYKTLFEAVLLVVIVVLVFLQSWRTALIPVIAIPVSLVGTF
                     AVMSALGFSLNNLTLFGLVLAIGIVVDDAIVVVENVERNMAEGLSAGEAAHKTMDEVGG
                     AVIAIALVLAAVFIPTAFIPGISGQFYKQFALTIAASTIISAFNSLTLSPALCKLL"
                     /label="MexAM1_META1p4956"
     gene            complement(6182..7324)
                     /locus_tag="MexAM1_META1p4957"
     CDS             complement(6182..7324)
                     /locus_tag="MexAM1_META1p4957"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="RND efflux transporter, membrane fusion protein
                     subunit"
                     /transl_table=11
                     /note="Evidence 2b : Function of strongly homologous gene;
                     Product type t : transporter"
                     /note="EFICAz EC number prediction: EC3: 2.3.1.-;
                     EFICAz_components: CHIEFc_SVM, MTTSI_bin: 0, Caution: LOW
                     CONFIDENCE prediction!"
                     /note="smCOG:
                     SMCOG1029:RND_family_efflux_transporter_MFP_subunit (Score:
                     218.4; E-value: 2.2e-66);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4957.png"
                     /db_xref="GI:240011338"
                     /EC_number="2.3.1.-"
                     /translation="MRSLRPLLLATPLIASALLGAGPAGAQMPGAPPPGVTVAKPVVRE
                     IVEQDQYTGRFDPIEFVEVRARVTGYLDKIMFQDGANVKKGEVLFIIDRRPYKAALEQA
                     QAALTSAKARLSFTQTDLERAQVLSRGGNISEQVTDQRRQASQTAQADVDSAEAALRNA
                     QLNYDFTEVKSPINGRISQRLVTEGNIVSTDQTILARIVSLDPVYFGFTVDERSFLKYQ
                     GSLGIGMGQMQRGKGAPVQIALSGEEKPTRKGTLDFVDNRVDNQTGTMLLRATVENPDN
                     FIKPGLFGIVAMPATKPFQGILIPDEAVSANQDKRIVYVLGDGDKVSARTVKLGPIVDG
                     YRVVRDGLKGDELVVVNGVAKVRPGAQVKPETVELPPSKK"
                     /protein_id="ACS42564.1"
     PFAM_domain     complement(6260..7192)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4957"
                     /description="HlyD family secretion protein"
                     /database="Pfam-A.hmm"
                     /evalue="3.00E-21"
                     /domain="HlyD_2"
                     /asDomain_id="fullhmmer_MexAM1_META1p4957_0002"
                     /note="Pfam-A.hmm-Hit: HlyD_2. Score: 75.9. E-value: 3e-21.
                     Domain range: 5..327."
                     /score="75.9"
                     /aSTool="fullhmmer"
                     /translation="EIVEQDQYTGRFDPIEFVEVRARVTGYLDKIMFQDGANVKKGEVL
                     FIIDRRPYKAALEQAQAALTSAKARLSFTQTDLERAQVLSRGGNISEQVTDQRRQASQT
                     AQADVDSAEAALRNAQLNYDFTEVKSPINGRISQRLVTEGNIVSTDQTILARIVSLDPV
                     YFGFTVDERSFLKYQGSLGIGMGQMQRGKGAPVQIALSGEEKPTRKGTLDFVDNRVDNQ
                     TGTMLLRATVENPDNFIKPGLFGIVAMPATKPFQGILIPDEAVSANQDKRIVYVLGDGD
                     KVSARTVKLGPIVDGYRVVRDGLKGDELVV"
                     /label="MexAM1_META1p4957"
     PFAM_domain     complement(6326..7141)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4957"
                     /description="HlyD family secretion protein"
                     /database="Pfam-A.hmm"
                     /evalue="9.60E-35"
                     /domain="HlyD"
                     /asDomain_id="fullhmmer_MexAM1_META1p4957_0001"
                     /note="Pfam-A.hmm-Hit: HlyD. Score: 120.3. E-value:
                     9.6e-35. Domain range: 1..283."
                     /db_xref="PFAM: PF00529"
                     /score="120.3"
                     /aSTool="fullhmmer"
                     /translation="VEVRARVTGYLDKIMFQDGANVKKGEVLFIIDRRPYKAALEQAQA
                     ALTSAKARLSFTQTDLERAQVLSRGGNISEQVTDQRRQASQTAQADVDSAEAALRNAQL
                     NYDFTEVKSPINGRISQRLVTEGNIVSTDQTILARIVSLDPVYFGFTVDERSFLKYQGS
                     LGIGMGQMQRGKGAPVQIALSGEEKPTRKGTLDFVDNRVDNQTGTMLLRATVENPDNFI
                     KPGLFGIVAMPATKPFQGILIPDEAVSANQDKRIVYVLGDGDKVSARTVK"
                     /label="MexAM1_META1p4957"
     PFAM_domain     complement(6467..6814)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4957"
                     /description="HlyD family secretion protein"
                     /database="Pfam-A.hmm"
                     /evalue="6.60E-10"
                     /domain="HlyD_3"
                     /asDomain_id="fullhmmer_MexAM1_META1p4957_0005"
                     /note="Pfam-A.hmm-Hit: HlyD_3. Score: 39.2. E-value:
                     6.6e-10. Domain range: 0..105."
                     /score="39.2"
                     /aSTool="fullhmmer"
                     /translation="EVKSPINGRISQRLVTEGNIVSTDQTILARIVSLDPVYFGFTVDE
                     RSFLKYQGSLGIGMGQMQRGKGAPVQIALSGEEKPTRKGTLDFVDNRVDNQTGTMLLRA
                     TVENPDNFIKPG"
                     /label="MexAM1_META1p4957"
     PFAM_domain     complement(6731..6814)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4957"
                     /description="Biotin-lipoyl like"
                     /database="Pfam-A.hmm"
                     /evalue="3.40E-04"
                     /domain="Biotin_lipoyl_2"
                     /asDomain_id="fullhmmer_MexAM1_META1p4957_0004"
                     /note="Pfam-A.hmm-Hit: Biotin_lipoyl_2. Score: 20.2.
                     E-value: 0.00034. Domain range: 3..31."
                     /score="20.2"
                     /aSTool="fullhmmer"
                     /translation="EVKSPINGRISQRLVTEGNIVSTDQTIL"
                     /label="MexAM1_META1p4957"
     PFAM_domain     complement(7001..7141)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4957"
                     /description="Biotin-lipoyl like"
                     /database="Pfam-A.hmm"
                     /evalue="7.60E-10"
                     /domain="Biotin_lipoyl_2"
                     /asDomain_id="fullhmmer_MexAM1_META1p4957_0003"
                     /note="Pfam-A.hmm-Hit: Biotin_lipoyl_2. Score: 38.3.
                     E-value: 7.6e-10. Domain range: 2..49."
                     /score="38.3"
                     /aSTool="fullhmmer"
                     /translation="VEVRARVTGYLDKIMFQDGANVKKGEVLFIIDRRPYKAALEQAQA
                     AL"
                     /label="MexAM1_META1p4957"
     PFAM_domain     complement(7049..7141)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4957"
                     /description="Biotin-requiring enzyme"
                     /database="Pfam-A.hmm"
                     /evalue="7.80E-03"
                     /domain="Biotin_lipoyl"
                     /asDomain_id="fullhmmer_MexAM1_META1p4957_0006"
                     /note="Pfam-A.hmm-Hit: Biotin_lipoyl. Score: 15.8. E-value:
                     0.0078. Domain range: 43..74."
                     /db_xref="PFAM: PF00364"
                     /score="15.8"
                     /aSTool="fullhmmer"
                     /translation="VEVRARVTGYLDKIMFQDGANVKKGEVLFII"
                     /label="MexAM1_META1p4957"
     gene            complement(7447..7770)
                     /locus_tag="MexAM1_META1p4958"
     CDS             complement(7447..7770)
                     /locus_tag="MexAM1_META1p4958"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="rhodanese domain protein, putative sulfur
                     transferase"
                     /transl_table=11
                     /note="Evidence 4 : Homologs of previously reported genes
                     of unknown function; Product type pe : putative enzyme"
                     /note="EFICAz EC number prediction: EC3: 2.8.1.-;
                     EFICAz_components: CHIEFc_SVM, MTTSI_bin: 2, Caution: LOW
                     CONFIDENCE prediction!"
                     /note="smCOG: SMCOG1163:rhodanese_domain-containing_protein
                     (Score: 50.6; E-value: 2.8e-15);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4958.png"
                     /db_xref="GI:240011339"
                     /EC_number="2.8.1.-"
                     /translation="MKVVDLDRETVKQGLADGSLLLIDVREDHEFARGRIPGSVSHPLS
                     SFDPEALKALIAADGRRPVFSCASGVRSVHAIAAAQQSGLDVSEHYAGAFKDWYAAGEP
                     VES"
                     /protein_id="ACS42565.1"
     PFAM_domain     complement(7471..7749)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4958"
                     /description="Rhodanese-like domain"
                     /database="Pfam-A.hmm"
                     /evalue="1.50E-12"
                     /domain="Rhodanese"
                     /asDomain_id="fullhmmer_MexAM1_META1p4958_0001"
                     /note="Pfam-A.hmm-Hit: Rhodanese. Score: 47.8. E-value:
                     1.5e-12. Domain range: 1..112."
                     /db_xref="PFAM: PF00581"
                     /score="47.8"
                     /aSTool="fullhmmer"
                     /translation="RETVKQGLADGSLLLIDVREDHEFARGRIPGSVSHPLSSFDPEAL
                     KALIAADGRRPVFSCASGVRSVHAIAAAQQSGLDVSEHYAGAFKDWYA"
                     /label="MexAM1_META1p4958"
     gene            complement(7819..9189)
                     /locus_tag="MexAM1_META1p4959"
     CDS             complement(7819..9189)
                     /locus_tag="MexAM1_META1p4959"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="putative Glycosyl transferase, group 1"
                     /transl_table=11
                     /note="Evidence 3 : Function proposed based on presence of
                     conserved amino acid motif, structural feature or limited
                     homology; Product type pe : putative enzyme"
                     /note="EFICAz EC number prediction: EC3: 2.4.1.-;
                     EFICAz_components: CHIEFc_SVM, MTTSI_bin: 2, Caution: LOW
                     CONFIDENCE prediction!"
                     /note="smCOG: SMCOG1045:glycosyl_transferase_group_1
                     (Score: 81.4; E-value: 1.2e-24);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4959.png"
                     /db_xref="GI:240011340"
                     /EC_number="2.4.1.-"
                     /translation="MQPAMQACLAIDLTRLITRLRHASPTGIDRVDLAYARHILSQGAE
                     GTCFGLVSTAYGPRVLDRATARGIVEAVAAGWVEDVVAEADPVFQALAASLAGDSHPFP
                     KAARRRAEGGLDRRRLQAETGLRVLRSGGIERLPEGTIYLHTSHLRLDRPERFDWLYSR
                     RDVRPVFFVHDLIPISHPEYGRPGEAERHAIRMETVARHAAQVLVNSGDVGARFTDYAR
                     QRGLGPTPVTVVPLGVEPVFSSGAGEAGLPALARPTFLVCGTIEPRKNHLLLLNLWRDL
                     AERNGAETGAAIPRLVLIGRRGWEIENVADMLDRCEAIRPHVSEVVGLSTHGLARLMRG
                     ATALLMPSFIEGYGLPVVEAAASGLPVVASDIPVHREIGSGFAHFLDPLDGPGWTAAVR
                     ALSEPGSRLRTELAGRLAAYEPPSWTAHFERVDAALASLPAAVAPHGREDLRNPRSM"
                     /protein_id="ACS42566.1"
     PFAM_domain     complement(7987..8418)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4959"
                     /description="Glycosyl transferases group 1"
                     /database="Pfam-A.hmm"
                     /evalue="5.70E-08"
                     /domain="Glyco_trans_1_4"
                     /asDomain_id="fullhmmer_MexAM1_META1p4959_0002"
                     /note="Pfam-A.hmm-Hit: Glyco_trans_1_4. Score: 32.9.
                     E-value: 5.7e-08. Domain range: 3..132."
                     /score="32.9"
                     /aSTool="fullhmmer"
                     /translation="TFLVCGTIEPRKNHLLLLNLWRDLAERNGAETGAAIPRLVLIGRR
                     GWEIENVADMLDRCEAIRPHVSEVVGLSTHGLARLMRGATALLMPSFIEGYGLPVVEAA
                     ASGLPVVASDIPVHREIGSGFAHFLDPLDGPGWTAAVRAL"
                     /label="MexAM1_META1p4959"
     PFAM_domain     complement(8056..8424)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4959"
                     /description="Glycosyl transferases group 1"
                     /database="Pfam-A.hmm"
                     /evalue="6.50E-13"
                     /domain="Glycos_transf_1"
                     /asDomain_id="fullhmmer_MexAM1_META1p4959_0001"
                     /note="Pfam-A.hmm-Hit: Glycos_transf_1. Score: 48.4.
                     E-value: 6.5e-13. Domain range: 14..130."
                     /db_xref="PFAM: PF00534"
                     /score="48.4"
                     /aSTool="fullhmmer"
                     /translation="RPTFLVCGTIEPRKNHLLLLNLWRDLAERNGAETGAAIPRLVLIG
                     RRGWEIENVADMLDRCEAIRPHVSEVVGLSTHGLARLMRGATALLMPSFIEGYGLPVVE
                     AAASGLPVVASDIPVHREI"
                     /label="MexAM1_META1p4959"
     gene            complement(9280..9828)
                     /locus_tag="MexAM1_META1p4960"
     CDS             complement(9280..9828)
                     /locus_tag="MexAM1_META1p4960"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="hypothetical protein"
                     /transl_table=11
                     /note="Evidence 5 : No homology to any previously reported
                     sequences"
                     /db_xref="GI:240011341"
                     /translation="MTTPGIVGTWEWDPATGCFILDEGAAELMAGDAGLAGHPLRSERA
                     TAGLDASVAARFLGDVRHAAEQEDDVAVDLWVPSLSGPKRRLLCRGRIHRDARQQPVRG
                     EGTLIDTADPGVQARTLRELEHAAAADAIDEAAGLIIAARRAIDASGKPRLRQLVDVLL
                     LEIAREIASRSTELDRQQH"
                     /protein_id="ACS42567.1"
     gene            complement(10001..10636)
                     /locus_tag="MexAM1_META1p4961"
                     /gene="mlaI"
     CDS             complement(10001..10636)
                     /function="3.1.2.4.4 : Quorum sensing"
                     /locus_tag="MexAM1_META1p4961"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="MlaI; autoinducer (N-acylhomoserine lactone)
                     synthase"
                     /transl_table=11
                     /note="Evidence 1a : Function experimentally demonstrated
                     in the studied strain; PubMedId : 16412429; Product type e
                     : enzyme"
                     /note="EFICAz EC number prediction: EC4: 2.3.1.184;
                     EFICAz_components: CHIEFc_SVM; PFAM_SVM, MTTSI_bin: 2,
                     Caution: LOW CONFIDENCE prediction!"
                     /note="EFICAz EC number prediction: EC3: 2.3.1.-;
                     EFICAz_components: CHIEFc_SVM; PFAM_SVM, MTTSI_bin: 2,
                     Caution: LOW CONFIDENCE prediction!"
                     /db_xref="GI:240011342"
                     /EC_number="2.3.1.184"
                     /sec_met="Type: hserlactone"
                     /sec_met="Domains detected: Autoind_synth (E-value:
                     4.7e-18, bitscore: 63.5, seeds: 13)"
                     /sec_met="Kind: biosynthetic"
                     /translation="MIHVVTAENMQDYAGALDQAFRLRHRVFVEELGWSNLARPDRREI
                     DEFDDEHAIHLLALDETESVIGYSRLLPTTRPYLLPMVLPQLCEGAAPSGAHIVEWGRI
                     CVAECARTSGRRLNPTALALMTAIVEWGLPRGITSFISEMPTSWILRLLQLHLRAMPLG
                     LPHEIEGEEIVAVEAAFDGRSLRQLQNKRGDIRSVLAPPRVSFARLAS"
                     /gene="mlaI"
                     /protein_id="ACS42568.1"
     PFAM_domain     complement(10211..10591)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4961"
                     /description="Autoinducer synthetase"
                     /database="Pfam-A.hmm"
                     /evalue="1.40E-17"
                     /domain="Autoind_synth"
                     /asDomain_id="fullhmmer_MexAM1_META1p4961_0001"
                     /note="Pfam-A.hmm-Hit: Autoind_synth. Score: 63.5. E-value:
                     1.4e-17. Domain range: 8..135."
                     /db_xref="PFAM: PF00765"
                     /score="63.5"
                     /aSTool="fullhmmer"
                     /translation="ALDQAFRLRHRVFVEELGWSNLARPDRREIDEFDDEHAIHLLALD
                     ETESVIGYSRLLPTTRPYLLPMVLPQLCEGAAPSGAHIVEWGRICVAECARTSGRRLNP
                     TALALMTAIVEWGLPRGITSFIS"
                     /label="MexAM1_META1p4961"
     PFAM_domain     complement(10298..10570)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4961"
                     /description="Acetyltransferase (GNAT) domain"
                     /database="Pfam-A.hmm"
                     /evalue="5.20E-13"
                     /domain="Acetyltransf_5"
                     /asDomain_id="fullhmmer_MexAM1_META1p4961_0002"
                     /note="Pfam-A.hmm-Hit: Acetyltransf_5. Score: 49.4.
                     E-value: 5.2e-13. Domain range: 0..93."
                     /score="49.4"
                     /aSTool="fullhmmer"
                     /translation="LRHRVFVEELGWSNLARPDRREIDEFDDEHAIHLLALDETESVIG
                     YSRLLPTTRPYLLPMVLPQLCEGAAPSGAHIVEWGRICVAECARTS"
                     /label="MexAM1_META1p4961"
     gene            complement(11115..11612)
                     /locus_tag="MexAM1_META1p4962"
     CDS             complement(11115..11612)
                     /function="3.1.2 : Transcriptional level"
                     /function="3.1.2.4.4 : Quorum sensing"
                     /locus_tag="MexAM1_META1p4962"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="N-acylhomoserine lactone transcriptional
                     regulator, LuxR family"
                     /transl_table=11
                     /note="Evidence 2b : Function of strongly homologous gene;
                     Product type pr : putative regulator"
                     /note="smCOG:
                     SMCOG1197:autoinducer-binding_transcriptional_regulator,
                     (Score: 131.3; E-value: 6.1e-40);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4962.png"
                     /db_xref="GI:240011343"
                     /translation="MYTDPVVQATLSSTTGFRWSEIEPAGVLDPRSRQVMNEAGEFGLG
                     DGFTVPLATLEEERGGLTFAGRQLDISPGQRGMLTLLASYVVGQTLLIDNGPSERRMGL
                     TPRERESLQWVAEGKTDWEIGELMGISRHGVDFHLRSARVKLGCVSRTQAVAEGFRRGL
                     II"
                     /protein_id="ACS42569.1"
     PFAM_domain     complement(11145..11306)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4962"
                     /description="Bacterial regulatory proteins, luxR family"
                     /database="Pfam-A.hmm"
                     /evalue="1.30E-15"
                     /domain="GerE"
                     /asDomain_id="fullhmmer_MexAM1_META1p4962_0002"
                     /note="Pfam-A.hmm-Hit: GerE. Score: 56.4. E-value: 1.3e-15.
                     Domain range: 2..56."
                     /db_xref="PFAM: PF00196"
                     /score="56.4"
                     /aSTool="fullhmmer"
                     /translation="GLTPRERESLQWVAEGKTDWEIGELMGISRHGVDFHLRSARVKLG
                     CVSRTQAVA"
                     /label="MexAM1_META1p4962"
     PFAM_domain     complement(11175..11303)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4962"
                     /description="Sigma-70, region 4"
                     /database="Pfam-A.hmm"
                     /evalue="9.80E-03"
                     /domain="Sigma70_r4_2"
                     /asDomain_id="fullhmmer_MexAM1_META1p4962_0004"
                     /note="Pfam-A.hmm-Hit: Sigma70_r4_2. Score: 15.3. E-value:
                     0.0098. Domain range: 10..54."
                     /db_xref="PFAM: PF08281"
                     /score="15.3"
                     /aSTool="fullhmmer"
                     /translation="LTPRERESLQWVAEGKTDWEIGELMGISRHGVDFHLRSARVKL"
                     /label="MexAM1_META1p4962"
     PFAM_domain     complement(11175..11306)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4962"
                     /description="Sigma-70, region 4"
                     /database="Pfam-A.hmm"
                     /evalue="2.70E-03"
                     /domain="Sigma70_r4"
                     /asDomain_id="fullhmmer_MexAM1_META1p4962_0003"
                     /note="Pfam-A.hmm-Hit: Sigma70_r4. Score: 16.9. E-value:
                     0.0027. Domain range: 3..48."
                     /db_xref="PFAM: PF04545"
                     /score="16.9"
                     /aSTool="fullhmmer"
                     /translation="GLTPRERESLQWVAEGKTDWEIGELMGISRHGVDFHLRSARVKL"
                     /label="MexAM1_META1p4962"
     PFAM_domain     complement(11355..11606)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4962"
                     /description="Autoinducer binding domain"
                     /database="Pfam-A.hmm"
                     /evalue="2.40E-18"
                     /domain="Autoind_bind"
                     /asDomain_id="fullhmmer_MexAM1_META1p4962_0001"
                     /note="Pfam-A.hmm-Hit: Autoind_bind. Score: 65.8. E-value:
                     2.4e-18. Domain range: 57..145."
                     /db_xref="PFAM: PF03472"
                     /score="65.8"
                     /aSTool="fullhmmer"
                     /translation="TDPVVQATLSSTTGFRWSEIEPAGVLDPRSRQVMNEAGEFGLGDG
                     FTVPLATLEEERGGLTFAGRQLDISPGQRGMLTLLASYV"
                     /label="MexAM1_META1p4962"
     gene            12166..12242
                     /locus_tag="MexAM1_META1ptRNA27"
     tRNA            12166..12242
                     /locus_tag="MexAM1_META1ptRNA27"
                     /inference="profile:tRNAscan:1.23"
                     /product="tRNA-Pro"
     mobile_element  12792..13991
                     /mobile_element_type="insertion sequence:ISMex1"
     gene            complement(14074..14331)
                     /locus_tag="MexAM1_META1p4966"
     CDS             complement(14074..14331)
                     /locus_tag="MexAM1_META1p4966"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="Hypothetical protein"
                     /transl_table=11
                     /note="Evidence 5 : No homology to any previously reported
                     sequences"
                     /db_xref="GI:240011344"
                     /translation="MVVANPESQSRPLQSELRRAGLKQSLPPSGGGWCCRRGRASPPHY
                     RACRRAGRSVRLGPLQRLSGDVLARMLLGSVHLVSADVGR"
                     /protein_id="ACS42570.1"
     gene            complement(14897..15856)
                     /locus_tag="MexAM1_META1p4967"
     CDS             complement(14897..15856)
                     /locus_tag="MexAM1_META1p4967"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="Transcriptional regulator, LysR family"
                     /transl_table=11
                     /note="Evidence 2b : Function of strongly homologous gene;
                     Product type r : regulator"
                     /note="smCOG:
                     SMCOG1125:LysR_family_transcriptional_regulator (Score:
                     285.3; E-value: 9.7e-87);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4967.png"
                     /db_xref="GI:240011345"
                     /translation="MRIDHVHLSRLDLNLLVALDALLTERSVTRAAGRIGISQSAMSHA
                     LARLRTAFSDELLTRGPDGMRPTPRALALLGPVQAALSQIQEITTPPAAFDPATADLTF
                     TLGIPDSTEVLLMPTLIAHLQAVAPGVKLLLHTVDRHRILDDLDTGRVDLGIGVFEQGQ
                     THHKRRILNKESYLCIFNAELVGVTAPISLDDYVRLPHLLTSLVESAHGVVDDALAKIG
                     RKRVIALTSPRFSVMPFVVRQAPVIATMHARLARFFADSMGLTVSPAPITLPDVSISMI
                     WHTSNDAIPSQRWLRETIIKLRKSDPRPPTDGSHATSD"
                     /protein_id="ACS42571.1"
     PFAM_domain     complement(14960..15550)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4967"
                     /description="LysR substrate binding domain"
                     /database="Pfam-A.hmm"
                     /evalue="2.90E-21"
                     /domain="LysR_substrate"
                     /asDomain_id="fullhmmer_MexAM1_META1p4967_0001"
                     /note="Pfam-A.hmm-Hit: LysR_substrate. Score: 75.5.
                     E-value: 2.9e-21. Domain range: 6..204."
                     /db_xref="PFAM: PF03466"
                     /score="75.5"
                     /aSTool="fullhmmer"
                     /translation="TFTLGIPDSTEVLLMPTLIAHLQAVAPGVKLLLHTVDRHRILDDL
                     DTGRVDLGIGVFEQGQTHHKRRILNKESYLCIFNAELVGVTAPISLDDYVRLPHLLTSL
                     VESAHGVVDDALAKIGRKRVIALTSPRFSVMPFVVRQAPVIATMHARLARFFADSMGLT
                     VSPAPITLPDVSISMIWHTSNDAIPSQRWLRETI"
                     /label="MexAM1_META1p4967"
     PFAM_domain     complement(15644..15820)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4967"
                     /description="Bacterial regulatory helix-turn-helix
                     protein"
                     /database="Pfam-A.hmm"
                     /evalue="1.30E-15"
                     /domain="HTH_1"
                     /asDomain_id="fullhmmer_MexAM1_META1p4967_0002"
                     /note="Pfam-A.hmm-Hit: HTH_1. Score: 56.8. E-value:
                     1.3e-15. Domain range: 0..59."
                     /db_xref="PFAM: PF00126"
                     /score="56.8"
                     /aSTool="fullhmmer"
                     /translation="LNLLVALDALLTERSVTRAAGRIGISQSAMSHALARLRTAFSDEL
                     LTRGPDGMRPTPRA"
                     /label="MexAM1_META1p4967"
     gene            15953..16204
                     /locus_tag="MexAM1_META1p4968"
     CDS             15953..16204
                     /locus_tag="MexAM1_META1p4968"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="conserved hypothetical protein"
                     /transl_table=11
                     /note="Evidence 4 : Homologs of previously reported genes
                     of unknown function"
                     /db_xref="GI:240011346"
                     /translation="MSKTFLSLTTAALAFTALATVPARAAEIGGAHNVKTVGALTLETQ
                     GVATSDLSVHRQGGFALPGSVQWIDTPADQVRTRQAAF"
                     /protein_id="ACS42572.1"
     gene            complement(16347..19526)
                     /locus_tag="MexAM1_META1p4969"
     CDS             complement(16347..19526)
                     /locus_tag="MexAM1_META1p4969"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="AcrB/AcrD/AcrF family protein"
                     /transl_table=11
                     /note="Evidence 2b : Function of strongly homologous gene;
                     Product type t : transporter"
                     /note="smCOG: SMCOG1049:AcrB/AcrD/AcrF_family_protein
                     (Score: 820.6; E-value: 3e-248);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4969.png"
                     /db_xref="GI:240011347"
                     /translation="MLDQRPARGPARDDPPGLSPAPVTLGPQAALVAFAVRRPGIVLAL
                     VLALAVYGIVALGSAKYDVFPEFAPPTVTVQTEAPGLNPEQVETLVTQTLEVAISGLPG
                     LATMRSNSIQGLSVITATFASGSDIYRARQLVNERLASITARLPQGVLPPTMTALTSST
                     SSVLLIGLTSPTQSLMDLRTVADWRLRLRLLAAPGVGEVLVYGGDLRSIRIQVRPQDLV
                     RFRIGLNDVLSAGRKATGVRGAGFVDTVNQRITLQTEGQSLTPEAVARTVLINEGGASV
                     VLGDVADVAVAPEPAISAALVDGKPGVLLMVGAQYGANTLDVTAGVEAALAEMRPGLER
                     DGTTLRTDLFRPASFVTQATDNVVQALALGGILVVVVLFVFLADWRTALISATAIPLSL
                     IGAVLMLGLFGQSLNTMTLGGLAIAIGEVVDDAVIGVENVMRRMRENRRAAAPLPGARV
                     VLDAILEVRVSVAYATFAVLLVFLPVLALTGVPGRLFGPLALAYILAVLTSLAVALTVT
                     PALARLLLAGRTNLPSREPPVSRRVRGVYISGLARLNRHPRLVFGTSLALTLVAALPVP
                     FFGGVFLPDLKEGHLILHMASAPGTSLQETLRLGGRITAGLKAVPGVRAVAQQVGRAEA
                     GYDLGGTHDSEIHIDLEPGLDGEGQERAEAGIRALMAATPGASFSLKTFLTERIEEVVS
                     GFTAPVVISVTGTNLDRIEATARDVARELAEVRGAADVQLKSPPGLPQVNVSLRPTDLR
                     HWGLDAIEVLEIVRTAYQGDIVGQAYEGNAVFNVVVVLEPIVRTRLSTLGNLPLRTPSG
                     SYIRLAQVADIYETAGRYAVGHIGAQRVRVVTANVEGRDVASFTEAAKRKIAREVAQPS
                     GIDIGFGGAAETQAKARRELALYAGLAGLGIVLLLLVVTGSLTNLALVLVNLPFAFVGG
                     VLAVALSGAVISLGSIVGFVTLFGISLRNTIMMVAHYEHLVLVEGRPWNLAAAIEGAAD
                     RLVPILMTSLVTGLGLLPLALGAGEPGREIEGPMALVILGGLATSTLLNLAVLPMLALR
                     FARFKPAEGAL"
                     /protein_id="ACS42573.1"
     PFAM_domain     complement(16392..19433)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4969"
                     /description="AcrB/AcrD/AcrF family"
                     /database="Pfam-A.hmm"
                     /evalue="4.50E-222"
                     /domain="ACR_tran"
                     /asDomain_id="fullhmmer_MexAM1_META1p4969_0001"
                     /note="Pfam-A.hmm-Hit: ACR_tran. Score: 739.4. E-value:
                     4.5e-222. Domain range: 1..1016."
                     /db_xref="PFAM: PF00873"
                     /score="739.4"
                     /aSTool="fullhmmer"
                     /translation="VAFAVRRPGIVLALVLALAVYGIVALGSAKYDVFPEFAPPTVTVQ
                     TEAPGLNPEQVETLVTQTLEVAISGLPGLATMRSNSIQGLSVITATFASGSDIYRARQL
                     VNERLASITARLPQGVLPPTMTALTSSTSSVLLIGLTSPTQSLMDLRTVADWRLRLRLL
                     AAPGVGEVLVYGGDLRSIRIQVRPQDLVRFRIGLNDVLSAGRKATGVRGAGFVDTVNQR
                     ITLQTEGQSLTPEAVARTVLINEGGASVVLGDVADVAVAPEPAISAALVDGKPGVLLMV
                     GAQYGANTLDVTAGVEAALAEMRPGLERDGTTLRTDLFRPASFVTQATDNVVQALALGG
                     ILVVVVLFVFLADWRTALISATAIPLSLIGAVLMLGLFGQSLNTMTLGGLAIAIGEVVD
                     DAVIGVENVMRRMRENRRAAAPLPGARVVLDAILEVRVSVAYATFAVLLVFLPVLALTG
                     VPGRLFGPLALAYILAVLTSLAVALTVTPALARLLLAGRTNLPSREPPVSRRVRGVYIS
                     GLARLNRHPRLVFGTSLALTLVAALPVPFFGGVFLPDLKEGHLILHMASAPGTSLQETL
                     RLGGRITAGLKAVPGVRAVAQQVGRAEAGYDLGGTHDSEIHIDLEPGLDGEGQERAEAG
                     IRALMAATPGASFSLKTFLTERIEEVVSGFTAPVVISVTGTNLDRIEATARDVARELAE
                     VRGAADVQLKSPPGLPQVNVSLRPTDLRHWGLDAIEVLEIVRTAYQGDIVGQAYEGNAV
                     FNVVVVLEPIVRTRLSTLGNLPLRTPSGSYIRLAQVADIYETAGRYAVGHIGAQRVRVV
                     TANVEGRDVASFTEAAKRKIAREVAQPSGIDIGFGGAAETQAKARRELALYAGLAGLGI
                     VLLLLVVTGSLTNLALVLVNLPFAFVGGVLAVALSGAVISLGSIVGFVTLFGISLRNTI
                     MMVAHYEHLVLVEGRPWNLAAAIEGAADRLVPILMTSLVTGLGLLPLALGAGEPGREIE
                     GPMALVILGGLATSTLLNLAVLPML"
                     /label="MexAM1_META1p4969"
     PFAM_domain     complement(17961..18455)
                     /detection="hmmscan"
                     /locus_tag="MexAM1_META1p4969"
                     /description="Protein export membrane protein"
                     /database="Pfam-A.hmm"
                     /evalue="5.90E-03"
                     /domain="SecD_SecF"
                     /asDomain_id="fullhmmer_MexAM1_META1p4969_0002"
                     /note="Pfam-A.hmm-Hit: SecD_SecF. Score: 15.8. E-value:
                     0.0059. Domain range: 27..184."
                     /db_xref="PFAM: PF02355"
                     /score="15.8"
                     /aSTool="fullhmmer"
                     /translation="QATDNVVQALALGGILVVVVLFVFLADWRTALISATAIPLSLIGA
                     VLMLGLFGQSLNTMTLGGLAIAIGEVVDDAVIGVENVMRRMRENRRAAAPLPGARVVLD
                     AILEVRVSVAYATFAVLLVFLPVLALTGVPGRLFGPLALAYILAVLTSLAVALTVTPAL
                     AR"
                     /label="MexAM1_META1p4969"
     gene            complement(19529..20635)
                     /locus_tag="MexAM1_META1p4970"
     CDS             complement(19529..20635)
                     /locus_tag="MexAM1_META1p4970"
                     /inference="ab initio prediction:AMIGene:2.0"
                     /codon_start=1
                     /product="hypothetical protein"
                     /transl_table=11
                     /note="Evidence 5 : No homology to any previously reported
                     sequences"
                     /note="smCOG:
                     SMCOG1029:RND_family_efflux_transporter_MFP_subunit (Score:
                     24.3; E-value: 1.156e-06);"
                     /note="smCOG tree PNG image: smcogs/MexAM1_META1p4970.png"
                     /db_xref="GI:240011348"
                     /translation="MRRVVLPVGLALGAGALGALTLTEAGIGLRVKAGPILSDLHDRFS
                     GVTTPAANQPPTAPSPPPSRVAVEGGQAVVRLTDAEQARIGVATARHKRMPHRIEVQAF
                     GSVLDLARVTELTNSYASARAQLQTAEAKAEVSRAAYTRARSLGQYATQVQLETAEGTF
                     RTDEAALAAAQSQVRTLAATAQQEWGTVIGRAIIERSPVITRLIERTDFLVQVTLPPGE
                     TLRAPPGTAHAEVPPQSERVALRYVSPATRTDQRIQGVSYFYTVAGNSGLLPGMSTLAF
                     LTSERETTGIAVPESAVVHWQGGAWIYRSVGDDAFARHPLRADAPISADAYVVDDLGAE
                     AEIVVTGPQAVLSEELKGQIQSSDADDD"
                     /protein_id="ACS42574.1"
ORIGIN
        1 gaaagttccg gttcgcgtcg agaaccgtcc catccatcgc gaactcaatg gtcgcgagcg
       61 atcgatcgag tgcatcgagc ttcgcttggg cgtcactttg cttgggctta cggaacatca
      121 cagaaccccc gtgacgcaat ctttctctgg cagccacgtc gccagagcga tgtcgtcatt
      181 gatcgagggc ggatctcggc gatttcgctc gatgtctttc atccgcccct tatgacgaat
      241 gttcattttc tgggtaaatt atggattaaa atctctggtg tagagcgttg caatcgtctg
      301 taggctgcaa tcttgtttcg acatgcgtcg cacagaccgc aactacgcta gtaacatatg
      361 atataaattc gccattgcgc tggcggtgtc tcctccccgt ccgcgtgggg ttcgaagatc
      421 agcccacttc gcagcctctt cgaggatagt cggaagggag cggccttcag accgctcgcc
      481 ctcccctgcg aaccggatgg gacgcgtgtc ttccgtccgg cccggcctgc gagcggtgtc
      541 gtcagtggcg ctcaggtgct gcggcgcaga tggtccagcg gcaccggtgc ggcgtggggc
      601 cggctgccga gcatggcatc gatcagcgcc acgacctcgg cccggccgac attggcggca
      661 ggctcgaacg gggtccaggt ctgggtgaaa tcgaggcgtt cgaacacgtc gcgatagcgg
      721 cgcagctcgt tcacggtgag cggcacgccg cgcacgaagg ccttgtgggc cgagatcgtc
      781 agcgccttgc gaaagtcgtt cgggtcgagc tcgaacttga gcgcgtcgcc gcagaaacag
      841 atcttgcgct tgcggtcgaa cagcacggcg tggccgtcga aatggccggc ggtgcggtgc
      901 agttccaagc cgggaagggg ttcgaggaag tcgtcgtagg gccaggagac ctgaagcgcc
      961 gcgctccaga tgaagtcggc cgccggcaga cacagttccg ggtcgaagcg gtcctgaagc
     1021 tgcaccagcg cgccgtagga atgcgggtgc gaggccgaga gcacctgcat cccgccgagc
     1081 cgctcgatct ggtcgagcgc cgcctcgctg aagacggggc aggcctcgaa gcccatattc
     1141 ccgttctcgg tccggatcag gtaggcgctc gggccgatgc cggaaaccgg atcgttccag
     1201 aaacgccaga ttccgggctc cagctcttcc cagtggcagg gaaaggcgtc ttgcgcctcg
     1261 cgcgtggtgc ggaagcgcca gccatcctgc ggcacgacgt gtcgggcgtc gaggcacatc
     1321 gggcaatgcg gcggcgcctc gaagtggcgc tgccagaacc cgcaattgtc gcaggtatag
     1381 gcgggcagct tcagggcgcc ggcgaagggc aggtaaccgg gcacgggcaa gtcctcatgg
     1441 gtgcccgcgg gcgggccgga gatcggacgg tcctatccgt ccgctgcggg tgaagaaagg
     1501 gctcgagccg tatccgacct gactgcatca ggccggcgct ctagctcttt gttttgacgt
     1561 gcattctctc gacgaaccgg tgaccacttc gtcggaatgc gctttcgctc agagccgccc
     1621 gagcagacgc agcggccggc gcagagcgcg cgccgccagg gcggttccga gcagggcggc
     1681 gccgacggca ccgagcacga gggcatcgcg ctcccggctg gtccagaact cggagcgggt
     1741 cgtcttggcc cgctcgctta tggcaccgtc gatgcgcgcc gcgcccggcg ccggtgcgtc
     1801 gaggttgccg cgccgatccg ggaccgcctt gtcctccacc atgtcgtccc aactctgcgc
     1861 cgccttgcgg tcggcgtagg acggcaggag ggcctgggcc gctgccatca gcaccgaggt
     1921 ccgtccgacc cagacctcgc gggtcggccg ctcggccgcg tggtggatcg cctcggcgca
     1981 caggcgtgga tcgaagacgg gatcgggggc gcgctgtccg tggccggtcc gggtgcgggt
     2041 ccagccgaat tgcggtgtgt tgaccgccgg caggtagacc acgctgagcg cgatcttgct
     2101 gttctcgtgg atcagttcgg cgcgcagcga gtcggtgaag ccgctgatcg cgaacttcgc
     2161 tgcgcaatag ggcgcctgga gcggagccgc acggatcgcc agccccgagg agacctgcac
     2221 gatcacgccg cggtcgcgcg gcttcatgcg gtgcagggcc gacagcgtgc cgtggacggt
     2281 gccgagatag gtcgccccgg tgacggtgcg gtactcctcc ggcgtgacct ggtcagccgg
     2341 gctgacgatc gtcgtcatgg cgttgttgat ccaggcccgg atcggcccga gctcctgctc
     2401 gatccggtcg gccgccgcct cgaccgccgc ggcgtcggcc acatcggccg ggatcgccag
     2461 cacgcgccca ccctcgcggg cgagcagcgc ctcggcctcg gcgagacgct cggcaccgcg
     2521 tgccaggatc gccaccgacc agccgcgttg cgcgaaaagc tgggccgtgg cgaggccgat
     2581 cccggcgctt ccgcccgtca ccacggcgac ccgcgcagca cctgttcgtc cctgccctgc
     2641 caaaccgtat cctcctgcgc tcaacctgcc cgtcaatgcg cgctgtgcgg gcggagttgc
     2701 ggcgggggcg acgctgcgac gatgcgagcc tggaccgttg gatacgagaa ggcccgccga
     2761 tccgaagatg ggcgggcctt ctcgatgttc agcgcttgcg cggggaggct cagccgtggg
     2821 ctggggctcc gtgcggcgcg ccatgcccgt cgccgccatg cgtgtccttg ccgcgcttcc
     2881 ttccgatcca gatcaccgcc ttgcggatca ccacgtagaa gaccggcgtc aggaacagac
     2941 cgaagaaggt cgcaccgatc atcccgaaga acaccgccgt gccgagcgcc tggcgcatct
     3001 cggcgccggg gcccgtggcg atcaccagcg gaagcacgcc gaggatgaag gcgaaggccg
     3061 tcatcaggat cgggcgcagg cgcaggcggc aggcctggac cgcggcatcc accgggccct
     3121 tgttctcgct gttctcgatg tcgtgggcga attccacgat caggatcgcg ttcttggcgg
     3181 ccagaccgat gagcacgatc agtccgatct gggtcaggat gttgttgtcc tgccctcgca
     3241 actgcacccc gaacagggcg gcgagcacgc ctgtcggcac caccagcagg atcgccagcg
     3301 gcagcgccca ggattcgtac tgcgccgcga gcacgaggaa gacgaggagc acgcccagcg
     3361 cgaagacgta gatcgccgtg tcgcccgccg ccttctgctg gaaggcgatc tcggtccagt
     3421 cgtaggaata gccctcgggc agggcccgct tggcgatctc ctccatggtg tcgagcgcct
     3481 gaccggtcga gacgccgggc tgcgccacgc cctgcagcgg caccgagtag tacaggttga
     3541 accgctgcac gatctgcggg ccggcgatgt cgcggatcga ggcgagcgtg cccatcggca
     3601 ccagggcgcc ggtcgaggag cgcaccttga gctgttcgat gtcccggcgc gacatgcggt
     3661 agaccgcgtc accctgcacg cgcacctgat agatgcggcc caaggtgttg aagtcgttga
     3721 cgtaggcgcc gcccaacgcc gtctgcacgg tcgagaagac gttggcgagc ggcacgttga
     3781 gcatgcgcgc gatggtgcgg tcgatgtcga ggtagagctg cggcgtgtcg ttgccgaagg
     3841 tcgtgaagac ccgcgtcaca tccttgctct ggttggcctg cccgatcacc tcgccggcgg
     3901 ccgcgagcag cggaccgatc tcggaggatt ggcggctctc gatctgcatc ttgaagccgc
     3961 cgccctggcc gaggccgcgc accggcggcg gcgggatgac gatgatgcgc gcttcctgga
     4021 tgccagccgt cgccttcagc acgtcgccgg tgatgacggc cgcgctccgg ccctgcgcgg
     4081 cccgttcctt ggcgcccttg agggtgagga acatcaccgc cgcgttggtg gtgttggtga
     4141 aggtcgcgcc gtcgaagccc gcgatgatga cggtgttggt gatgccgtcg acgccgcggg
     4201 cgattttggc ggcacggttc acggcatcgg tggtgcggtc gagcgaggag cccgcgggca
     4261 actgcacgac gccgatgagg tagccctgat cctggtccgg gatgaagccc gtgggcgtcg
     4321 tccgggcgag gtgcagcgtg cccgcgatca cgccggcata taggatcagc atggcgatca
     4381 cgccgatggc cgtccccgtc aggaagcgga tcgagtgggc gtagccgttc gacagcgcgt
     4441 cgaagccgcg gttgaacagg tgcgccagcc agttgaggaa gcgggtgagg aagaatttcg
     4501 gcggcttgtg ctcgtggtgc ggcttcagca gcagcttgca gagcgccggc gacagggtga
     4561 gcgagttgaa ggccgagatg atggtcgagg ccgcgatggt gagcgcgaac tgcttgtaga
     4621 actggcccga gatgccgggg atgaaggcgg tcgggatgaa caccgccgcc agcacgaggg
     4681 cgatggcgat gaccgccccg cccacctcgt ccatggtctt gtgggccgcc tcgccggccg
     4741 agagcccctc ggccatgttg cgctcgacgt tctccaccac gacgatcgcg tcgtcgacca
     4801 cgatgccgat ggcgagcacg agaccgaaca gggtgaggtt gttgagcgag aagcccagcg
     4861 ccgacatcac cgcgaaggtg ccgaccagcg acacgggaat cgcgatcacc gggatcagcg
     4921 ccgtgcgcca gctctggagg aagacgagca cgacgatgac gacgaggagg accgcctcga
     4981 acagggtctt gtagacctcg tggatcgact cctcgatgaa ctccgtcggg ttgtaggcga
     5041 tgcggtactc gacgtccggc gggaagttct tcttcaactg ctccatcgtc gccttgaccg
     5101 attccgcggc ctcgagcgcg ttggtgcccg gccgctggaa ggcgccgatg ccgaccgcgg
     5161 gcgtgtcgtt gaggaaggag ttcgtcgtgt agtccttctg gcccatctcg acgcgggcga
     5221 tgtcgcgcac gcgcacgagg cgcccgtcat tcgccttgac gatgacgtcg gcgaactgct
     5281 ccggcgactg aaagcgccct tgcgactgaa ccacgagctg gaaggcggcg cccggcgcgg
     5341 cgggcgggcc gttgagctgg ccggccgcga cctgcacgtt ctgctcctgc agcgcgctcg
     5401 tcacgtcggt ggtggtcagg ccgtaggcgg ccatcttctg cggatcgatc cagacccgct
     5461 cggcatactc gttgccgccg aagatcgaga tgtcgccgac gccgtcgagg cgcagcagct
     5521 cgtcgcggat gttgaggtag atgtagttgg ccagatagtt ctggtcgtag gtgcgcttgg
     5581 gcgagagcag gtgcacgacc agcatcaggt cgggcgaggc cttgcgcacg gtgacgccga
     5641 ggttgcgcac gtccggcggc aggcgcggct gcgccaccga gagacggttc tggacgagca
     5701 cgttggcgat atcgaggttg gtgccgacct tgaaggtcac ggtcagcagc atcgcgccgt
     5761 cgttggtcga caacgacgtc atgtagagca tgttgtcgac gccgttgatc tcctgctcca
     5821 gcggcgtcgc gatcgtggcg gccaccgttt cggcgttggc gccggggaag ctcgcgcgca
     5881 cggtcacggt cggcggcacg atctcgggat attgcgagac cggcagcttc tcgtaggcga
     5941 cgaagccgac gatcaggaag atgatcgacg tgaccgaggc gaagatcggc cggtcgacga
     6001 agaaatgggc gaaacgcatc gttcaaacct ctcgccggcc ggtgcgcgct ggcgcgaccc
     6061 gtgcggcttg ccgtctgcgt ccaggccggc atccccggtc ggtccgggag cgtcggcgct
     6121 cgaaaatctt tactgtccgc gtcccgcctc gcccccgcga cggtgccgca tcaccgcgac
     6181 gtcacttctt cgacggcggc agctcgaccg tctcgggctt cacctgcgcg cccgggcgga
     6241 ccttggcgac gccgttgacc accacgagtt cgtcgccctt caggccgtcg cggaccacgc
     6301 ggtagccgtc gacgatcggc ccgagcttca cggtcctggc cgagaccttg tcgccatcgc
     6361 cgagcacgta gacgatgcgc ttgtcctggt tggccgagac cgcctcgtcg gggatcagga
     6421 tgccctggaa cggcttggtc gcgggcatcg cgacgatgcc gaacaggccc ggcttgatga
     6481 agttgtccgg gttctcgacg gtggcgcgca ggagcatcgt gccggtctgg ttgtcgaccc
     6541 ggttgtcgac gaagtcgagc gtgcccttgc gggtcggctt ctcctcgccg gacagggcga
     6601 tctgcaccgg agcgcccttg ccgcgctgca tctggcccat gccgatgccg agtgagccct
     6661 ggtatttcag gaacgagcgc tcatcgacgg tgaagccgaa atagaccgga tcgagcgaga
     6721 cgatccgggc caggatcgtc tggtcggtgc tgacgatgtt gccctcggtg acgagacgct
     6781 ggctgatccg cccgttgatc ggcgatttca cttccgtgaa gtcgtagttg agctgcgcgt
     6841 tgcgaagcgc cgcttccgcg ctgtccacgt cggcctgggc ggtctgcgag gcctgacggc
     6901 gctggtcggt gacctgctcg gagatgttgc cgccgcgcga cagcacctgg gcacgctcca
     6961 gatccgtctg ggtgaaggag agccgcgcct tggccgaggt gagcgcggcc tgggcttgct
     7021 ccagagccgc cttgtagggg cggcggtcga tgatgaagag cacttcgccc ttcttcacgt
     7081 tcgcgccgtc ctggaacatg atcttgtcga ggtagccggt tacgcgggcg cggacctcga
     7141 cgaattcgat cgggtcgaac cggccggtat actggtcctg ctcgacgatc tcccgcacca
     7201 ccggcttggc gacggtcacg ccgggcggcg gcgcgcccgg catctgcgcg ccagccggcc
     7261 cggcacccag cagcgcggag gcgatcagcg gtgtggcgag tagaagaggc ctgaggctac
     7321 gcatcattcg gttccctgca tggcgcggcc tagtccccgc aacctcgagt ggggcgtgcg
     7381 ctcccgcaca tggcggtcca tcgcggaagg aacggttcgg cgctctgcaa cgcaggcgtg
     7441 ccgtatctag gattcaaccg gttctccggc ggcgtaccaa tccttgaagg cccccgcgta
     7501 atgctcgctc acatcgaggc cggattgctg cgcggcggcg atcgcatgga cggagcgcac
     7561 gcccgaggcg caggagaaga ccgggcggcg cccgtccgct gcgatcagcg ccttcaaggc
     7621 ttcagggtca aagctcgaga gcgggtgcga gacggagccg ggaatgcgcc cacgggcgaa
     7681 ttcatgatcc tcacgcacat cgatgagcag cagcgagccg tccgccaagc cctgcttgac
     7741 cgtctcgcgg tcgaggtcga ccaccttcat cgcaaccgat ctttccaaag ggagggagcc
     7801 gccgcggaag ggggcgggtc acatcgagcg gggatttctt aagtcttctc gcccgtgcgg
     7861 cgcaacagcg gcgggcaggc tggcgagtgc ggcatcgacc cgctcgaaat gcgcggtcca
     7921 gcttggcggt tcgtaggcag cgagccgccc cgccagctcc gtccgcaacc gggagcccgg
     7981 ttcgctcaag gcccgcaccg ccgccgtcca gcccggtccg tcgagcggat cgaggaaatg
     8041 ggcgaaaccg ctgccgatct cccggtgcac ggggatgtcg gaggcgacga ccggaaggcc
     8101 gctggcggcg gcttcgacca ccggcaggcc gtagccttcg atgaaggagg gcatcagcag
     8161 ggcggtggcg ccccgcatca accgcgcgag gccgtgggtg gacaggccga ccacctcgct
     8221 cacatgcggg cggatggcct cgcagcggtc gagcatgtcg gcgacgttct cgatctccca
     8281 gccgcgccgg ccgatcagga cgagccgcgg gatcgccgca ccggtctcgg cgccgttgcg
     8341 ctcggcgaga tcgcgccaga ggttgagcag cagcaggtgg ttcttgcgcg gctcgatcgt
     8401 gccgcaaacg aggaaggtcg gccgcgcgag cgccggcagc cccgcctcgc ccgcgccgct
     8461 cgagaagacg ggctcgacgc cgagggggac cacggtcacc ggcgtcgggc ccaggccccg
     8521 ctgccgcgcg taatccgtga agcgggcgcc gacatcgccc gaattgacga gcacctgcgc
     8581 ggcgtggcgc gccacggtct ccatccggat cgcgtggcgc tcggcctcgc ccggccggcc
     8641 gtattcgggg tgggagatcg gaatcaggtc gtggacgaag aagaccggcc gcacgtcgcg
     8701 ccgcgaatag agccaatcga agcgttcggg ccggtcgagc cgcaggtgcg aggtgtgaag
     8761 atagatcgtt ccctcgggca ggcgctcgat cccgcccgag cgcagcaccc gcaatccggt
     8821 ttcggcctga aggcgacgtc ggtcgagccc gccctccgcc cggcgccgtg ctgccttcgg
     8881 gaacgggtgg gagtcgcccg caagcgaggc cgcgagcgcc tgaaacaccg gatcggcctc
     8941 ggcgaccacg tcctcgaccc agcccgcggc gaccgcctcg acgatgccgc gcgcggtcgc
     9001 gcggtcgagg acgcgcgggc cgtacgccgt cgagacgagc ccgaagcacg tgccctccgc
     9061 gccctgggac aggatgtgcc gggcataggc aagatcgacc cggtcgatgc cggtcgggct
     9121 ggcatgacgg agccgagtga tgagacgggt caggtcgatg gcgagacagg cttgcatggc
     9181 cggctgcata gaccggattc cgtgatcctg gcgaccgtca ccgggtcatc gctgcaggtc
     9241 tttggccgcg ggtctttggt caggccttgc gccgcggatc tagtgctgtt gccgatccag
     9301 ctcggtgctg cggctcgcga tctcccgggc gatctcgagc aggaggacat cgacgagctg
     9361 gcgcagccgg ggcttgccgc tggcatcgat cgcacggcgc gccgcgatga tgagtccggc
     9421 agcctcgtcg atggcatcgg ccgcggccgc gtgttccagc tcccgcaggg tccgtgcctg
     9481 cacaccggga tcggcggtgt cgatcagcgt cccctccccg cgcacgggtt gctgccgcgc
     9541 gtcccggtga atccggccgc ggcacaaaag ccggcgcttg ggtccggaga gtgagggaac
     9601 ccagagatcg accgcgacgt cgtcctcctg ctcggcggcg tggcggacgt cgccgaggaa
     9661 gcgggcggcc accgacgcat cgaggcccgc ggtcgcccgc tcgctgcgca gggggtgtcc
     9721 ggcaaggccg gcatcccccg ccatcaactc ggcggctccc tcgtcgagga tgaagcatcc
     9781 ggtcgccgga tcccactccc aggttccgac gattccaggc gtcgtcatgg ttccggcgag
     9841 ccccggaacc gttgcgtacc gggcgtcact gcgtctgcgt ttcaaggtac tactccccgc
     9901 gcacaaagcg tcaggcttgt gatggctgcg tcctgccagg gcggccggat cgcggtgccg
     9961 atgtccggcg acggatgcgg cgcacccgtc gccgcgtccg tcaggaggcg agccgggcga
    10021 agctgacccg cggcggggcc agcaccgagc ggatgtcgcc gcgcttgttc tggagctggc
    10081 gcagcgagcg gccgtcgaag gccgcctcga ccgcgacgat ctcctcgccc tcgatttcgt
    10141 ggggcaggcc gaggggcatc gcgcgcaggt gcagttgcag caggcgcagg atccagctcg
    10201 tcggcatttc ggagatgaag ctggtgatcc cccgcggcag cccccactcg acgatggccg
    10261 tcatcagggc cagggccgtc gggttgagcc gccggcccga ggtccgggcg cattccgcga
    10321 cgcagatgcg gccccattcg acgatatgcg cgcccgacgg cgccgcccct tcgcaaagct
    10381 gtggcaacac catcggcagc aggtagggcc gggtcgtcgg caacaggcgc gaatagccga
    10441 tgacggactc ggtttcgtcg agggcgagga ggtggatggc gtgctcgtcg tcgaactcgt
    10501 cgatttcgcg ccggtccggg cgagcgaggt tggaccagcc cagttcttcg acgaagacac
    10561 ggtgtctcag gcggaaggcc tgatcgagcg caccggcata gtcctgcatg ttttcagcgg
    10621 tgacgacatg gatcatcgga acacctcttc agaaacctga agtgttcgtc ccaaatccag
    10681 tcgtgtcgcg gcactacgag aacccgtagg gtttcgttcg ggcggtcttt tgccgttcgg
    10741 gaattaagcc agtccgcgag cgcttattcc gccactctcg caaatcgcgc ggcccacgtc
    10801 tctatcttgg attgaatgtg taaaacaata cagaacttgc cgacagccgg cggaggagcg
    10861 gctcacatta ccgtggtcat gagcgctgcg gcgcgatcct gcaccgcgtc cgcgcggctc
    10921 caagcgccgg cggatggcgt cgccccgtgc agcgatccgg atatcgcgcc gggcgcgatg
    10981 cgccggacat gcaatcttgc attgcctgtt ttcgaaagct cgccacgcgc ggtgcttcgg
    11041 tcgcgccgcg gctcaccctt ccggcggctc ttcgacctga gtcgggcggt cgatggcggc
    11101 acggtctggt ccgctcagat gatcaggccg cgcctgaacc cctcggccac cgcttgtgta
    11161 cgggacacgc agccgagttt cacccgggcg gagcgcagat ggaaatcgac gccgtgccgc
    11221 gagatgccca tcaactcgcc gatttcccaa tcggtcttgc cctcggcgac ccattgcagg
    11281 ctctcgcgtt cgcgcggggt cagtcccatc cggcgttcgc tggggccgtt gtcgatgagc
    11341 agcgtctgcc cgaccacgta ggaggcgagc agggtgagca tcccgcgctg tcctgggcta
    11401 atatcgagct gccgacccgc gaaggtgagg ccgccgcgct cctcctccag cgtggcgagc
    11461 ggcaccgtaa agccgtcgcc gaggccgaac tcgccggcct cgttcatcac ctgccgcgag
    11521 cgggggtcga gcacgcccgc cggttcgatc tccgaccagc ggaagccggt cgtgctggac
    11581 agggtcgcct gcacgaccgg gtccgtatac atatagccct tcgaaaagta gagccggttc
    11641 cactcgtcgg gagtattctc taaaataagg tagttctttt gtgtccgcgc cggcaggcgt
    11701 ttcagtggaa tcatcgccga gatgacgtat tcgatgccca gcgcgttgag ccgcggcatg
    11761 atggcccgca ggatatcctc acgcgaatgc gctcgatcga gcgacttcag aatttccaac
    11821 gtcaggtcaa gcgattttct agacatggcc cggcaaaatc atcgcactct catcacgata
    11881 agtcgttgct acgcctttga gaagggcgct cgcaaatttc gttgaagttg cttcgctgtt
    11941 gcctgcgcgg agtcaacgac acagggagcc ggcgcgcccc ctgtctgccg tcctgcgcga
    12001 cgccgtacgg ccgagcaatg cgctgaatca aatttcgagg gtcggcacgc gctcgtgcac
    12061 aggtctcgtc cgcagggtga aggaccgcac cctgcggttc ggcgttcgcg gaagggcttg
    12121 cgctgtccga agcggaccgc tatgagccgc gggccgtaag ggcgtcggag tgtagcgcag
    12181 cccggtagcg cacctgtctg ggggacaggg ggtcgtcggt tcaagtccgg ccactccgac
    12241 catttctttt cgatgacctg tggcaggctc agcttcccgc gctgccgccg ttttgcaggt
    12301 tgtttgcagc ttcctgttca ggcgctgttc gctgagcttc gctatcgccg actcgaccaa
    12361 cgtctgaggc taggctagat accggtctag aatcttttgt gcgagcgcct gtcagtgacc
    12421 catagtggtc gcgatccgca ccagatggta gcaggtgttg cgggtctcgc ccttcggatc
    12481 cgtgccgcgc atcgcgacgt agcccttcgc cggcgtgccg ccgcgcagcc gtctgcgctt
    12541 gcttggcgtc agtcgaagtc gctcgaacct aggtgaccgg cgacgtcatt acccggatgg
    12601 agcgccgcgt tgacaatctc gtgtcctcgg tacgtgacga aatgaaggag acgcgcgaga
    12661 cgatgctcaa agccatcatg ggacgctcgt ccggctgatc ccgccaagca tcctcgacca
    12721 cgctaccgcc ccgaggcttc agcctcgggg ttttttctta tgcccaagat gccgcctgag
    12781 ttggtgcttg gtgaccttgc cccctgtttg cccccgttca taaccagagt ccgttctggt
    12841 tctggtcctg tcgggaccgg gttgcaaacg cgttcggggt gagcccgccg aggctcgtgt
    12901 gggggcggca ggtgttatag tcgacccgcc acgcctcgat gatggtccgg gccgccggca
    12961 ggctccggaa cagatgctcg ttcaggcact cgtcgcgcaa gcgcccgttc aagctctcga
    13021 caaaaccgtt ctgctgcggc ttgccgggcg cgatgtaatg ccactcgacc gcacgctcct
    13081 cctgccagcg caggatggcg tgcgaggtca gctcggtgcc gttgtccgag acgatcatca
    13141 gcggcttgcc ccggcccttg atgatccggt cgagttcacg cgtgacccgc cgcccggaca
    13201 gcgacgtgtc gaccaccagc gccaggcact cccgcgtgca gtcatcgacc acgacgagga
    13261 tgcggaagcg ccgcccgtcg tcgagcgtgt cggagacgaa gtcgaggctc cagcgctggt
    13321 tcggctcctg cggcaccgcg gcgggcgctc gcgtgccaag tgctcgcttg cgacctccgc
    13381 gcttgcgcac cgacagccgc tcctctcggt agagccggaa gagcttcttg tggttgagag
    13441 cgaggccctc ccgccgcagt aggatgagca ggcgccggta gccgaaccgg cggcgctcgc
    13501 cggccaggcc gcgcaggcgc acccgcacag ccgcgtcgtc accacgggtc gaggcgtagc
    13561 ggtacgtctt cggctcaagg ccgatcagcc cgcaggcacg acgctgcgaa taacctttct
    13621 cctcgatggc ccagctcacg gccgttctcc gtgcgccggg cgtcagaagt tttttcccag
    13681 cgcctcacgc agcgtggcca cgtcgagcat cgcctcggcc aggagcttct tgagcttgcg
    13741 gttctcctca tcgagcgcct tcagacgccg cgcgtccgag acctccatgc cgccgaagcg
    13801 cgagcgccac gtgtagaacg tcgcgtcgct gatgccgtgg cggcgacaga tctcagccac
    13861 cggcagccca gcctgctgct ccttcaggat gccgatgatc tgctcttcgc taaaccggct
    13921 cttcttcatc gtccgtctcc tgctcgacgg accctagctt cagaatgagg gcaggccagg
    13981 gggcaaggtc acgaagcctc ctaattgctg ggctgagcta gcacatcgga tcaataggcg
    14041 tcacctgtgc cgcccagcca atcccgccgc atatcagcgt cccacatcgg cgctgacgag
    14101 atgcacggag ccgagcaaca ttctcgccag cacatctcca ctcagacgtt gcagcggtcc
    14161 caatcgcact gagcggccag cgcgtctgca agcacggtag tgaggcggac tcgctcgacc
    14221 tctacggcag caccatccac cgccactggg cggcagcgac tgcttcaacc cggcacgacg
    14281 aagttcggat tgtaaagggc gtgattggct ctcgggattg gccacgacca aactcgccca
    14341 gccgtgcccg gcgacggccg cggcgagctc caggctgtat ccttcggcga tcaggtgggt
    14401 ggtggtgccg agatcggctt ggtcagcatc gaccgccccg tttacttgct tggcggttac
    14461 ggccttggcc ttgaagattt agccgactgt ggggagggat cgccatccga cgagccgaac
    14521 tcgcgggcca ttcggcgacc agcacaccgc gcgcaaggca gtcgaggcgg atgatatccg
    14581 ctttgcgaaa tccgcctaag tcattgctac ttctaacgca tactttcgga atttggtgga
    14641 aaagatgctg gctttctata atctaggcca atctgggcgg gcacaaggcg tcggttcaag
    14701 tccggccact ccgaccattc attgccgaga ccgcattccc gccggggaac gatgccgtct
    14761 cgcacccccc ctctctctgc cgccgtgatg ctcgcgaccg ccttcaggcc gttgccgagg
    14821 cgatgacgcc ggtgcacggc tgatgcggga agcccacggc gcctgagcga cgccgccatc
    14881 cgtcatcccg aagggatcaa tcggatgtcg cgtgagagcc gtcggtcggc ggccggggat
    14941 cggatttgcg tagctttatg atggtctccc gcagccagcg ctgactggga atggcgtcgt
    15001 tggacgtgtg ccagatcatc gagatggaga cgtccggcag cgtgatcggt gccgggctga
    15061 cggtcaggcc catgctgtcg gcgaagaagc gcgcgagccg ggcgtgcatc gtggcgatga
    15121 cgggggcttg ccgcaccacg aagggcatca ccgagaaccg cggcgaggtc agcgcgatga
    15181 cgcgcttgcg gccgatcttg gccagcgcgt cgtccaccac gccgtgggcg ctctcgacca
    15241 ggctcgtgag caggtgcggg agccgcacgt agtcgtcgag cgagatcggc gccgtcaccc
    15301 caaccagctc ggcgttgaag atgcagaggt agctctcctt gttgaggatg cgtcgcttgt
    15361 ggtgcgtctg gccctgctcg aacacgccga tgccgagatc gacccgcccc gtatcgaggt
    15421 cgtcgaggat gcggtgccga tcgaccgtgt gcagcaggag cttcaccccc ggtgccaccg
    15481 cctgcagatg cgcgatgagg gtcggcatca ggagcacctc ggtcgagtcc gggatgccga
    15541 gggtgaaggt gaggtcggcc gtggccggat cgaaggcagc cggcggcgtc gtgatctcct
    15601 gaatctggga cagtgccgct tgcaccggcc ccaggagcgc cagcgcgcgc ggcgtcggcc
    15661 gcatgccgtc gggcccccgc gtcagcagct catccgagaa ggcggtgcgc agccgcgcca
    15721 gggcatggct catcgcggac tggctgatgc cgatccgtcc ggctgcgcgg gtcacgctcc
    15781 gctccgtcag cagcgcgtcg agggcgacga gcaggttgag atcgagccgg gatagatgca
    15841 cgtgatcgat gcgcattatg aaatcgatcc atttgattca tgggccatga cccagcacat
    15901 acagtctcac gaagcgacgg ggagcccgcc gcacgaaaag aggctgatct cgatgtccaa
    15961 gacctttctc tcgctcacca ccgccgcgtt ggccttcact gcgcttgcca cggtgcccgc
    16021 ccgcgccgcg gaaatcggcg gcgcccacaa cgtcaagacg gtcggcgcgc tgaccctgga
    16081 aactcagggt gtggccacca gcgatctctc ggtccaccgc cagggcggct tcgccctccc
    16141 cggctcggtc cagtggatcg atacaccagc cgatcaggtg agaacccggc aggccgcctt
    16201 ctgagccggc gtcgtgagac gcctagacgg aacagatgac cctccggcgc cagatggcgc
    16261 cggagacgtt ttaaaagggt acaggacagg cccgcgggcc aacgccccgt cagaatagga
    16321 agcgggatct cgcatccgtc cgacggtcac agcgcgcctt ccgcgggctt gaaccgggcg
    16381 aagcgcaggg ccagcatcgg cagcacggcg aggttgagca aagtcgaggt cgcgaggccg
    16441 ccgaggatga ccagggccat cgggccctcg atctcccggc cgggttcacc cgcaccgagc
    16501 gccagcggca acagcccgag gccggtgacg agggacgtca tcaggatcgg cacgagacgg
    16561 tcggcggcgc cctcgatggc ggccgcgagg ttccagggcc gcccttccac cagcaccaga
    16621 tgctcgtaat gcgcgaccat catgatggtg ttgcgcagcg agatgccgaa cagggtcacg
    16681 aagccgacga tcgagcccag cgagatcacc gcgccgctca aggccaccgc cagcacgccg
    16741 ccgacgaagg cgaagggcag gttgacgagg acgagggcaa gattggtcag cgagccggtc
    16801 acgacgagga gcaggagcac gatcccgaga ccggcgagac ctgcgtagag cgcgagttcg
    16861 cgccgcgcct tggcctgcgt ctcggccgcc cccccgaatc cgatatcgat gcccgagggc
    16921 tgcgcgacct cgcgggcgat cttccgtttc gcggcctcgg tgaaggaggc gacgtcgcgc
    16981 ccctccacat tcgcggtcac gacccgcacc cgctgcgcgc cgatatggcc gacggcgtag
    17041 cggccggcgg tctcgtagat gtcggcgacc tgggcgagcc ggatgtagct gccgctcggc
    17101 gtgcgcagcg gcaggttgcc gagcgtcgag aggcgcgtgc gtacgatcgg ttcgagcacg
    17161 acgacgacgt tgaacacggc gttgccctcg taggcttggc cgacgatgtc gccctgatag
    17221 gccgtgcgca cgatttccag gacttcgatc gcgtcgaggc cccagtggcg caggtcggtc
    17281 gggcgcaggc tcacattgac ctggggcagg cccggcggcg acttgagctg gacgtcggcc
    17341 gcaccgcgca cctcggcgag ttcgcgcgcc acgtcgcggg cggtggcctc gatccggtcg
    17401 agattcgtgc cggtgacgct gatcacgacc ggcgcggtga accctgagac gacctcctcg
    17461 atgcgctcgg tcaggaaggt cttgagcgag aagctcgcgc cgggcgtcgc cgccatcagt
    17521 gcgcggatgc cggcctccgc ccgctcctgc ccctccccgt cgaggcccgg ttcgaggtcg
    17581 atatggatct cgctgtcatg cgtgccgccg agatcgtagc ctgcctcggc gcgcccgacc
    17641 tgctgggcca ccgcgcgcac gccgggcacc gccttcagcc ccgccgtgat gcgcccgccg
    17701 agcctcagcg tctcctgaag ggaggtgccg ggggccgagg ccatgtgcag gatgagatgc
    17761 ccctccttga ggtccggcag gaacacgccg ccgaagaacg gcaccggcag ggctgctacg
    17821 agcgtcaggg cgaggctggt gccgaagacg agacgcgggt gacggttgag ccgcgcgagc
    17881 ccgctgatat agacgccccg cacgcggcgg ctgaccggcg gctcgcggct cggcaggttg
    17941 gtgcgcccgg cgagcagcag gcgggccagt gcgggcgtga ccgtcagcgc cacggcgagc
    18001 gaggtcagca cggcgaggat gtaggccagc gccaacgggc cgaacagccg accgggcacg
    18061 ccggtcaggg ccagcaccgg caggaacacg agcagcaccg cgaaggtggc gtaggcgacc
    18121 gagacgcgca cttccaggat cgcgtcgagc accacccgtg cgccgggtaa gggcgcggcg
    18181 gcgcggcggt tctcgcgcat gcggcgcatg acgttctcga cgccgatcac cgcgtcatcg
    18241 accacttcgc cgatggcgat ggcgaggccg cccagcgtca tggtgttgag gctctggccg
    18301 aacaggccga gcatcagcac cgcgccgatc agggagagcg ggatcgccgt ggcgctgatc
    18361 agcgccgtac gccagtcggc caggaagacg aacagcacca cgacgacgag gatgccgccg
    18421 agtgccagcg cctggaccac gttgtcggta gcctgcgtga cgaagctcgc cgggcggaac
    18481 aggtcggtgc gcagggtggt gccatcgcgc tccagcccgg ggcgcatctc ggcgagcgcc
    18541 gcctcgacgc cggccgtcac gtcgagggtg ttggcgccgt attgcgcgcc gaccatcagc
    18601 agcacgcccg gtttgccatc gacgagggcc gcgctgatcg ccggctccgg cgccaccgcc
    18661 acgtcggcga cgtcgccgag caccacgctc gccccgccct cgttgatgag cacggtgcgc
    18721 gccaccgcct ccggggtcag ggattgccct tcggtctgca gggtgatgcg ctggttgacg
    18781 gtatcgacga agcccgcccc gcgcacgccc gtcgccttgc ggccggccga gagcacgtcg
    18841 ttcaggccga tgcggaagcg caccagatcc tgcggccgga cctggatacg gatcgagcgg
    18901 agatcgccgc catagaccag cacctcgccg acgccggggg cggcgagcag gcgcaggcgc
    18961 agacgccaat cggccaccgt gcgcaggtcc atcagcgact gcgtcgggga ggtcaggccg
    19021 atgaggagga ccgaactcgt cgaggaggtc agcgccgtca tggtgggggg cagcacgccc
    19081 tgcggcaacc gcgcggtgat ggaggccaga cgctcgttca cgagctggcg ggcccggtag
    19141 atgtcgctgc cggaggcgaa ggtggcggtg atgaccgaga ggccctggat cgagttcgag
    19201 cgcatcgtcg ccagtcccgg caggccgctg atcgcgacct ccagcgtctg cgtcaccagg
    19261 gtctcgacct gttcggggtt gaggccgggc gcctcggtct gcaccgtcac cgtgggcgga
    19321 gcgaattccg ggaagacgtc gtatttggcc gaacccaagg cgacgatgcc gtagacggcg
    19381 agcgccagga ccagcgccag gacgataccg ggccggcgca ccgcgaaggc gaccagggcg
    19441 gcctgagggc ccaaggtcac gggcgcaggg gagaggcccg gcggatcgtc gcgcgccggt
    19501 ccgcgtgcgg gccgttggtc gagcatgctc aatcgtcgtc cgcatccgag gactggatct
    19561 gccccttcag ctcctcggag agaaccgcct gcggccccgt cacgacgatc tccgcctccg
    19621 cgccgagatc gtccacgacg taggcgtcgg ccgagatcgg cgcgtcggct cggaggggat
    19681 ggcgcgcaaa ggcgtcgtcg ccgacgctcc ggtagatcca ggcgccgccc tgccagtgca
    19741 ccacggcgct ttccggcacg gcgatgcccg tcgtctcgcg ctccgaagtc aggaaggcga
    19801 gcgtgctcat gcccggcagg agcccgctgt tgccggccac ggtgtagaag tagctgacgc
    19861 cctgaatgcg ctggtcggtc cgggtcgcgg gcgagacgta gcgcagcgcg acgcgctcgc
    19921 tctgcggcgg cacctcggca tgggccgtgc cgggcggcgc ccgcagcgtc tcgccgggcg
    19981 gcagcgtcac ctgcaccagg aagtcggtgc gctcgatcag ccgggtgatg acgggcgaac
    20041 gctcgatgat ggcccgcccg atcaccgtgc cccattcctg ctgcgcggtg gccgcgaggg
    20101 tccggacctg cgactgcgcc gcggcgagcg ccgcctcgtc cgtgcggaag gtgccctcgg
    20161 ccgtctccag ctgcacctgt gtcgcgtact ggccgaggct gcgcgcccgg gtgtaggcgg
    20221 cgcgcgagac ttccgccttg gcttcggcgg tctgcaactg cgccctggcg ctggcgtagc
    20281 tgttggtgag ttccgtgacc cgcgcgagat cgaggaccga gccgaaggcc tggacctcga
    20341 tgcggtgggg catccgctta tggcgcgccg ttgcgacgcc gatccgcgcc tgctccgcat
    20401 cggtcagccg cacgacggcc tgaccgcctt ccaccgcgac tcgcgagggc ggggggctcg
    20461 gtgcggtcgg cggctgattc gccgcgggcg tcgtcacccc ggaaaaccga tcatgcaggt
    20521 ccgagaggat ggggccggcc ttcacgcgca ggccgatgcc ggcttcggtc agcgtgagcg
    20581 caccgagcgc acccgcgccg agcgccagcc ccacgggcag gacgacccgc cgcatc
//
