LOCUS       CP001280               10840 bp    DNA              UNK 01-JAN-1980
DEFINITION  Methylocella silvestris BL2, complete genome.
ACCESSION   CP001280
VERSION     CP001280.1
KEYWORDS    .
SOURCE      .
  ORGANISM  .
            .
FEATURES             Location/Qualifiers
     cluster         1..10840
                     /note="Cluster number: 12"
                     /note="Detection rule(s) for this cluster type:
                     bacteriocin: (strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or
                     Bacteriocin_Iii or Cloacin or Linocin_M18 or TIGR03603 or
                     TIGR03604 or TIGR03605 or TIGR03651 or TIGR03678 or
                     TIGR03693 or TIGR03798 or TIGR03882 or TIGR03601 or
                     TIGR03602 or TIGR03795 or TIGR03793 or TIGR03975 or
                     DUF692);"
                     /clusterblast="2. JNCF01000058_c1	Legionella norrlandica
                     strain LEGN contig_68, whole genome... (7% of genes show
                     similarity)"
                     /clusterblast="3. CP003885_c2	Legionella pneumophila subsp.
                     pneumophila LPE509, complete gen... (7% of genes show
                     similarity)"
                     /clusterblast="4. CP003730_c7	Legionella pneumophila subsp.
                     pneumophila str. Thunder Bay, co... (7% of genes show
                     similarity)"
                     /clusterblast="5. CP003192_c6	Legionella pneumophila subsp.
                     pneumophila ATCC 43290, complete... (7% of genes show
                     similarity)"
                     /clusterblast="6. AE017354_c6	Legionella pneumophila subsp.
                     pneumophila str. Philadelphia 1,... (7% of genes show
                     similarity)"
                     /clusterblast="7. CR628337_c5	Legionella pneumophila str.
                     Lens complete genome. (7% of genes show similarity)"
                     /clusterblast="8. FQ958211_c6	Legionella pneumophila subsp.
                     pneumophila str. HL06041035 chro... (7% of genes show
                     similarity)"
                     /clusterblast="9. CR628336_c5	Legionella pneumophila str.
                     Paris complete genome. (7% of genes show similarity)"
                     /clusterblast="10. AWES01000008_c2	Legionella pneumophila
                     str. Leg01/20 Leg01_20_c16, whole ... (7% of genes show
                     similarity)"
                     /clusterblast="11. AVOW01000031_c1	Legionella pneumophila
                     str. Leg01/53 Leg01_53_c30, whole ... (7% of genes show
                     similarity)"
                     /product="bacteriocin"
     gene            complement(1078..1713)
                     /locus_tag="Msil_3688"
     CDS             complement(1078..1713)
                     /locus_tag="Msil_3688"
                     /codon_start=1
                     /product="DSBA oxidoreductase"
                     /transl_table=11
                     /note="PFAM: DSBA oxidoreductase; KEGG: met:M446_0134 DsbA
                     oxidoreductase"
                     /db_xref="GI:217505163"
                     /db_xref="InterPro:IPR001853"
                     /translation="MLNVSRRGLLAGAVMAVCIGAASAAPLSADDPDLSREALLSDPAT
                     PVGGDPNGDVTIVAFFDYNCPFCMKSEPALERLIASDKNIRLVYKDWPIFGGVSVYAAK
                     LALAANFQGKYAAAHHALMATSRRKSSEAEARQLVAAAGVDMARLDADFSGKAAQIDAI
                     LKRTEKQATGMGFAGTPVYLIGPFLVAAALDFDGFKKAVADARAKREP"
                     /protein_id="ACK52572.1"
     sig_peptide     complement(1624..1713)
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 1.000) with cleavage site probability 0.637 at
                     residue 30"
                     /locus_tag="Msil_3688"
     gene            complement(1770..2270)
                     /locus_tag="Msil_3689"
     CDS             complement(1770..2270)
                     /locus_tag="Msil_3689"
                     /codon_start=1
                     /product="protein of unknown function DUF1178"
                     /transl_table=11
                     /note="PFAM: protein of unknown function DUF1178; KEGG:
                     xau:Xaut_3087 hypothetical protein"
                     /db_xref="GI:217505164"
                     /db_xref="InterPro:IPR009562"
                     /translation="MIKFSLRCANGHEFESWFKEGVAFDAQAEAGLISCPTCQSASVSK
                     AIMAPALARRDRVEGPPAASAQGAPAQSAPAPDVPAPAGGPVEIFSAADTKLREMIAEF
                     RQRVLDNSDDLGDKFAEEALKIHHGLAPDRPIHGQASHDNVRLLIEEGVNILPLPRAPG
                     EFN"
                     /protein_id="ACK52573.1"
     gene            complement(2267..2530)
                     /locus_tag="Msil_3690"
     CDS             complement(2267..2530)
                     /locus_tag="Msil_3690"
                     /codon_start=1
                     /product="glutaredoxin 3"
                     /transl_table=11
                     /note="TIGRFAM: glutaredoxin 3; PFAM: glutaredoxin; KEGG:
                     bid:Bind_3310 glutaredoxin 3"
                     /db_xref="GI:217505165"
                     /db_xref="InterPro:IPR002109"
                     /db_xref="InterPro:IPR011767"
                     /db_xref="InterPro:IPR011900"
                     /db_xref="InterPro:IPR014025"
                     /translation="MAQITIYTTSTCPYCIRAKALLEKKKLEFTEISVDGDPKLRSELA
                     ERTGRSSVPQVFIGESHVGGCDDLYELHYDGKLEQLIADHAQ"
                     /protein_id="ACK52574.1"
     gene            2654..3130
                     /locus_tag="Msil_3691"
     CDS             2654..3130
                     /locus_tag="Msil_3691"
                     /codon_start=1
                     /product="ferric uptake regulator, Fur family"
                     /transl_table=11
                     /note="PFAM: ferric-uptake regulator; KEGG: met:M446_2230
                     ferric uptake regulator, Fur family"
                     /note="smCOG:
                     SMCOG1266:hydrogen_peroxide_sensitive_repressor (Score:
                     55.6; E-value: 9.7e-17);"
                     /note="smCOG tree PNG image: smcogs/Msil_3691.png"
                     /db_xref="GI:217505166"
                     /db_xref="InterPro:IPR002481"
                     /translation="MPRLNSKSRRAADQQKAPLGQLRGCPFHELRVKFAATGLRPTRQR
                     LSLGWLLFSRGDRHLTAENLAEEAQASNVPVSLATIYNSLHQFSGAGLLREVAVDGTRT
                     YFDTNTLIHHHFLIDGTLVDIPEVKIDPLDLPPPPPGKRVAAIEVVVHLRDASA"
                     /protein_id="ACK52575.1"
     gene            3146..4192
                     /locus_tag="Msil_3692"
     CDS             3146..4192
                     /locus_tag="Msil_3692"
                     /codon_start=1
                     /product="Ferrochelatase"
                     /EC_number="4.99.1.1"
                     /note="PFAM: ferrochelatase; KEGG: mex:Mext_1470
                     ferrochelatase"
                     /db_xref="GI:217505167"
                     /db_xref="InterPro:IPR001015"
                     /translation="MTAETAAVDARPVASSQRVGVLLVNLGTPDALGYWPVRRYLKEFL
                     SDRRVVNTPRLIWWPILNLIILTTRPQRSSKNYETIWNSQRNESPLKTVTRSQAEQLAG
                     SIVSGEFGAGGDIVVDWAMRYANPSILSSLQRLREQGCGRVLIVPLYPQFAGATTLSVA
                     DKVEESLARMNWRPDMRSVPPYYNDPVYIDALAQSVRAGLAALDFEPEVVLVSFHGIPK
                     SYVEAGDPYYDQCVETWRLLRERLDFSPERCPLTFQSRFGRAEWLSPYTDETVKELARK
                     GVRRMAVLTPGFSVDCLETISEIGVENREFFIEAGGEQFALIPCLNDSALGMKVIRHIV
                     SRELEGWI"
                     /transl_table=11
                     /protein_id="ACK52576.1"
     gene            complement(4189..5004)
                     /locus_tag="Msil_3693"
     CDS             complement(4189..5004)
                     /locus_tag="Msil_3693"
                     /codon_start=1
                     /product="conserved hypothetical protein"
                     /transl_table=11
                     /note="KEGG: bbt:BBta_3397 hypothetical protein"
                     /db_xref="GI:217505168"
                     /translation="MTLKQSQSLFQSAILSGGEAAPSGVEDGPRLNAAARFKIYSDAYR
                     LRLAECLSAEYPALRERLGDEAFGALFEAYLEQRPSRAFAAQDYCRGLPDFMREDPDWR
                     ERDEALGLAEFERALSHAFDAPDAPQLAIEVLAAHSPEEWPELTFALHPSVRMIALPHA
                     ARRAYELSQSEPIEAADAANANDLESSPMETMLFWRQRDLSFYRALGGEEELALATLMR
                     GADFGLICAVLAQNRGVEDVAGEAAGFLARWFADGLIAGVGAEPAGSRA"
                     /protein_id="ACK52577.1"
     gene            complement(5001..5840)
                     /locus_tag="Msil_3694"
     CDS             complement(5001..5840)
                     /locus_tag="Msil_3694"
                     /codon_start=1
                     /product="protein of unknown function DUF692"
                     /transl_table=11
                     /note="PFAM: protein of unknown function DUF692; KEGG:
                     bbt:BBta_3398 hypothetical protein"
                     /db_xref="GI:217505169"
                     /db_xref="InterPro:IPR007801"
                     /sec_met="Type: bacteriocin"
                     /sec_met="Domains detected: DUF692 (E-value: 1.9e-102,
                     bitscore: 339.9, seeds: 7)"
                     /sec_met="Kind: biosynthetic"
                     /translation="MQKPAPLGFGLGLRHRYYAEIIEQRPDIDWFEIISENYIGRGGRP
                     LAILDDIRANYPIVMHGVSMSIASTAPLDFHYLGKLRDLARRCEPEWISDHLCWTGVHG
                     VNLHDLLPIPYTREALHHVAERILRVQDFLQRRIAIENVSSYVTFAESEMTEEVFLREL
                     AEKADCWLLLDVNNVFVSSFNHGFDPARFLDDIPQERVLQFHLAGHSDHETHKIDTHDQ
                     PVIEEVWSLFERACRRFGAISTMIERDDNFPPLQELVAELDRARAVALSASAKQAAE"
                     /protein_id="ACK52578.1"
     gene            complement(5927..6211)
                     /locus_tag="Msil_3695"
     CDS             complement(5927..6211)
                     /locus_tag="Msil_3695"
                     /codon_start=1
                     /product="conserved hypothetical protein"
                     /transl_table=11
                     /note="KEGG: mpt:Mpe_A2832 hypothetical protein"
                     /db_xref="GI:217505170"
                     /translation="MTSSHDLGVRTSKVASGASLAIAAIALAMNGAALSPAAAKSAKTV
                     HCMGINSCKGTSACKTAENACKGQNSCKGHGWLPAKSTSACTSKGGTVI"
                     /protein_id="ACK52579.1"
     sig_peptide     complement(6092..6211)
                     /note="Signal predicted by SignalP 3.0 HMM (Signal peptide
                     probability 0.997) with cleavage site probability 0.655 at
                     residue 40"
                     /locus_tag="Msil_3695"
     gene            complement(6328..7317)
                     /locus_tag="Msil_3696"
     CDS             complement(6328..7317)
                     /locus_tag="Msil_3696"
                     /codon_start=1
                     /product="UDP-glucose 4-epimerase"
                     /transl_table=11
                     /note="TIGRFAM: UDP-glucose 4-epimerase; PFAM:
                     NAD-dependent epimerase/dehydratase; short-chain
                     dehydrogenase/reductase SDR; 3-beta hydroxysteroid
                     dehydrogenase/isomerase; polysaccharide biosynthesis
                     protein CapD; dTDP-4-dehydrorhamnose reductase; Male
                     sterility domain; KEGG: bid:Bind_1866 UDP-glucose
                     4-epimerase"
                     /note="smCOG: SMCOG1010:NAD-dependent_epimerase/dehydratase
                     (Score: 253.0; E-value: 7.2e-77);"
                     /db_xref="GI:217505171"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002225"
                     /db_xref="InterPro:IPR003869"
                     /db_xref="InterPro:IPR005886"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="InterPro:IPR013120"
                     /sec_met="NRPS/PKS subtype: PKS/NRPS-like protein"
                     /sec_met="NRPS/PKS Domain: NAD_binding_4 (64-194). E-value:
                     4.2e-12. Score: 37.2;"
                     /translation="MTVLVTGGAGYIGGHMALALLDQGEEVVVLDNLSTGFAWAVPPAA
                     KLIVGDFGDSALVDQIFADHRIDAIAHFAAKIVVPESVSDPLAYYLNNTAKARNLLECA
                     VKAGVKQFIFSSTAAVYGEPAENPVFENVALAPINPYGRSKLMVEWMLADVAAAHQLRY
                     VVLRYFNVAGADPAGRLGQSSPVATHLIKVAVQAALGHRDGLDVFGTDYPTPDGSCVRD
                     YIQVTDLVDAHLLALAHLRAGGGSLTCNCGYGRGLSVLEVVEVVKKVSGVDFEVRLKGR
                     RPGDPASLVAGADRVRQELGWTPKHDNLAEIVEQALSWERRLHNRKAG"
                     /protein_id="ACK52580.1"
     aSDomain        complement(6736..7125)
                     /domain="NAD_binding_4"
                     /database="nrpspksdomains.hmm"
                     /evalue="4.20E-12"
                     /locus_tag="Msil_3696"
                     /asDomain_id="nrpspksdomains_Msil_3696_Xdom01"
                     /detection="hmmscan"
                     /score="37.2"
                     /translation="HRIDAIAHFAAKIVVPESVSDPLAYYLNNTAKARNLLECAVKAGV
                     KQFIFSSTAAVYGEPAENPVFENVALAPINPYGRSKLMVEWMLADVAAAHQLRYVVLRY
                     FNVAGADPAGRLGQSSPVATHLIKVA"
     CDS_motif       complement(7228..7314)
                     /detection="hmmscan"
                     /locus_tag="Msil_3696"
                     /motif="PKSI-KR_m1"
                     /database="abmotifs"
                     /evalue="7.20E-05"
                     /asDomain_id="nrpspksmotif_Msil_3696_0001"
                     /note="NRPS/PKS Motif: PKSI-KR_m1 (e-value: 7.2e-05,
                     bit-score: 15.5)"
                     /score="15.5"
                     /aSTool="pksnrpsmotif"
                     /translation="TVLVTGGAGYIGGHMALALLDQGEEVVVL"
                     /label="PKSI-KR_m1"
     gene            7613..8500
                     /locus_tag="Msil_3697"
     CDS             7613..8500
                     /locus_tag="Msil_3697"
                     /codon_start=1
                     /product="UTP-glucose-1-phosphate uridylyltransferase"
                     /EC_number="2.7.7.9"
                     /note="KEGG: bid:Bind_0435 UTP-glucose-1-phosphate
                     uridylyltransferase; TIGRFAM: UTP-glucose-1-phosphate
                     uridylyltransferase; PFAM: Nucleotidyl transferase"
                     /note="smCOG:
                     SMCOG1064:glucose-1-phosphate_adenylyl/thymidylyltransferas
                     e (Score: 202.5; E-value: 1.4e-61);"
                     /note="smCOG tree PNG image: smcogs/Msil_3697.png"
                     /db_xref="GI:217505172"
                     /db_xref="InterPro:IPR005771"
                     /db_xref="InterPro:IPR005835"
                     /translation="MTKRIRKAVFPVAGLGTRFLPATKSIPKEMLTIVDRPVLQHVVEE
                     AAEAGIEHFIFVTGRGKAVIEDHFDIAYELDDTLQKRGKLKEFNALKEQLPAAGATSFT
                     RQQAPLGLGHAIWCARELVGDEPFAVLLPDMVTMAGPQSSGRCLSQCIEAYAKHGGNII
                     AVEEVAPEETHQYGIVSIGRDFGSSFEITGMVEKPPQGTAPSNCIISGRYLLGPEIFKI
                     LEKVEKGAGGEIQLTDGMKELAATQSFHGVRFDGKTYDCGSKLGFLSANVAFALSNPDI
                     AGAFKAELKKFGPF"
                     /transl_table=11
                     /protein_id="ACK52581.1"
     gene            complement(8540..9634)
                     /locus_tag="Msil_3698"
     CDS             complement(8540..9634)
                     /locus_tag="Msil_3698"
                     /codon_start=1
                     /product="NADH:flavin oxidoreductase/NADH oxidase"
                     /transl_table=11
                     /note="PFAM: NADH:flavin oxidoreductase/NADH oxidase; KEGG:
                     bja:bll2445 oxidoreductase"
                     /note="smCOG:
                     SMCOG1217:NADH:flavin_oxidoreductase/NADH_oxidase (Score:
                     387.5; E-value: 9e-118);"
                     /note="smCOG tree PNG image: smcogs/Msil_3698.png"
                     /db_xref="GI:217505173"
                     /db_xref="InterPro:IPR001155"
                     /translation="MTADANVLFSPFTLGDLRLPNRIVMAPLTRSRATKGTLAPSDLNA
                     TYYRQRASAGMIISEASQISQEGQGYFATPGIYSEEQVEGWKKVTDAVHEEGGLIFIQL
                     WHVGRYSHVSLQPGGGAPVAPSAIAAKGQTFIESGLAPVSAPRALALDEIPRVVADYRR
                     AAENAKRAGFDGVEIHGANGYLIDQFLKDGTNKRDDSYGGSVENRTRFALEVTDAILAV
                     WDKSRVGIRLSPVSPVNDAVDSAPEKVFFPLVAALSQRGLAYIHVIEGATGGARDNAPF
                     DFPAFRKSFSGAYIANNAYTRDLAIEALEADRADLIAFGKLFISNPDLVERLRENAPLN
                     APHVETFYGGAAEGYTDYPALDDA"
                     /protein_id="ACK52582.1"
     gene            complement(9745..9999)
                     /locus_tag="Msil_3699"
     CDS             complement(9745..9999)
                     /locus_tag="Msil_3699"
                     /codon_start=1
                     /product="conserved hypothetical protein"
                     /transl_table=11
                     /note="KEGG: bid:Bind_3227 hypothetical protein"
                     /db_xref="GI:217505174"
                     /translation="MTKDIAESGVAAAELTQFVERVERLEEEKKALSDDIRDVYAEMKA
                     RGFDVKVVRQIVRLRKQDHAERMEMEAILELYMSALNMK"
                     /protein_id="ACK52583.1"
ORIGIN
        1 gatgagggcg agatcaagcc ttatctgcag ctcggcaaat tgatcgaggc cgccttctac
       61 gccgcgggcc ggctgtttgg gctcagtttt accgaacgct tcgacattcc gctctacaac
      121 aagggcgcgc gcgcctttga agtcgcgcgg gacggcaagc cggtcgcgct gttcatcggc
      181 gattatctgg cgcggccgtc caaacgcagc ggcgcttgga tgagcgattt tcgcggccag
      241 cacaaactcg acggcgcgca attgcccatc atcgtcaatg tcatgaattt tgcgcagggc
      301 ggcgagggcg agccaagcct gctcagcttc gatgacgcgc gcacgctgtt ccatgaattc
      361 ggccacggtc tgcatggcat gctgtccgac gtgacctatc cgacgctttc gggcaccaat
      421 gtcgcgcgcg acttcgttga atttccctcg cagctctatg agcattggct ggagcagccc
      481 gagattttgc gtcgcttcgc gctgcattat gagacgggtg agccgatgcc ggaggcgctc
      541 atcgaaaagc tcgtcgccgc gcgaaaattc aatcagggct tcgcgacgct cgaatatgcc
      601 gcctccgcgc tggtcgacct cagcctgcat ctgaacgcga cgccggagga tctcgacgtc
      661 gtcgcgctcg aacagaagga gctggcgcgc atcggcatgc cggaggccat cgccatgcgt
      721 caccgcacgc cgcatttcca gcacatcttt tcgggcgaat cctattcggc cggctactac
      781 agctatctct ggtcggaaat tctcgacgcc gacggttttg aggccttcca cgagaccggc
      841 gacatcttcc atacggagac ggcgcggcgg ctgcatgatt tcgtctatgc cgccggcggc
      901 agccgcgact atgaggacgc ctacgcagga tttcgcgggc gggcgccctc gccacaggcg
      961 ctgctgcgaa agcgcggcct ggatagtgcg gcggcggcga gttagctccg tttgaaacgg
     1021 gggcgtcctt cggcaagctc aggacacgag ggcggcaaca gcgcgccgaa tgaagtctca
     1081 gggctcgcgc ttcgcccgcg cgtcggcgac ggctttcttg aagccgtcga aatcgagcgc
     1141 cgccgcgacg aggaagggcc cgatcagata gaccggcgtt ccggcaaagc ccatgccggt
     1201 cgcctgcttc tcggtgcgct tcaatatcgc gtcgatctgc gcggcttttc cggagaaatc
     1261 ggcgtcgagc cgggccatgt cgacgccggc cgcggcgaca agttggcgcg cttcggcctc
     1321 actcgacttg cggcgggacg tcgccatcag cgcgtgatgc gcggcggcat atttgccctg
     1381 aaaattcgcc gcgagcgcga gtttggcggc gtagacagaa accccgccaa agatcggcca
     1441 gtccttatag acgaggcgga tatttttatc ggacgcgatc agccgctcca gcgccggctc
     1501 cgacttcatg cagaagggac aattataatc gaagaaggcg acgatggtga cgtcgccgtt
     1561 cggatcgccg ccgacggggg tcgcgggatc gctcaagagg gcttcgcggc tgagatcggg
     1621 atcgtccgcg gagagcggcg cggcggacgc ggcgccgatg caaacagcca ttacggcgcc
     1681 tgccagcagg ccccgccgcg aaacattcag catttcagtg agctccgcgc gggaatttgg
     1741 ccttccgtcc ggggagggcg gcgcgctctt cagttgaatt cgcctggcgc gcgcggcagc
     1801 ggcaggatgt tgacgccctc ttcgatcagc aggcgaacgt tgtcgtggct cgcctgaccg
     1861 tggattggcc gatccggcgc caggccgtga tggatcttca acgcttcctc ggcaaatttg
     1921 tcgccgagat cgtcggagtt atcgagcacg cgctggcgga actcggcgat catctcgcgc
     1981 aattttgtgt ccgcggcgct gaaaatctcg accgggccgc cggcaggcgc cggcacatcg
     2041 ggcgcaggcg cgctttgcgc aggcgcgccc tgcgccgaag cggcgggcgg cccttcaacc
     2101 cggtcgcggc gggccagcgc gggagccatg atcgccttgg agacggaggc gctctggcat
     2161 gtcgggcagg aaatcaggcc ggcttcggcc tgcgcgtcaa aagccacgcc ctctttgaac
     2221 cagctttcga actcgtgacc attggcgcaa cgcagcgaaa atttgatcat tgcgcgtgat
     2281 cggcgatcag ctgctcgagc ttgccgtcgt agtgaagctc atacaaatcg tcgcagccgc
     2341 cgacatggct ttcgccgatg aagacctgcg gcacgctgct gcggccggtg cgctcggcca
     2401 gctcgctccg gagttttggg tcgccgtcga cggagatttc ggtgaactca agcttcttct
     2461 tttccaacag cgccttggcc ctgatgcaat aggggcaggt cgacgtggta tagatcgtaa
     2521 tttgcgccat ccggtgatcc tcttcgccga ctataaaaga aaaaatatcg gtttcacaag
     2581 cgccggcggc gcgcggttgc cgatcgggcg ggggcgccct attcttgatt tcctgttctc
     2641 atgagagcgc ttgatgccaa gattgaactc gaaatcgcgc cgcgccgcag accagcagaa
     2701 ggcgccgctg ggacagcttc gcgggtgccc gtttcacgaa ctccgcgtca aattcgccgc
     2761 cacggggctg cggccgacgc ggcagcggct ctccctcggc tggcttttgt tctcgcgcgg
     2821 ggaccggcac ctgaccgccg aaaatctggc cgaagaggcg caggcctcca acgttccggt
     2881 ctcgctcgcg accatctaca acagcctgca ccagttcagc ggcgcgggcc ttctgcgcga
     2941 ggttgccgtc gacggcacca gaacctattt cgacaccaat acgctgatcc accaccattt
     3001 tctgatagat gggacgctgg tcgacattcc ggaagtgaaa atcgatcccc ttgatctgcc
     3061 gccgccgccg ccgggaaaac gcgtcgcggc gatcgaagtg gtcgtacatc ttcgcgacgc
     3121 gtccgcctga gagaaaacgc ccgccatgac cgctgagacc gccgctgtcg acgcgcgtcc
     3181 cgtcgccagc tcccagaggg ttggcgtgct gctcgtcaat ctcggcacgc cggatgcgct
     3241 cggctattgg cctgtgcgcc gctatctgaa agagtttttg tccgacaggc gcgtcgtcaa
     3301 cacgccccgc ctgatctggt ggccgattct caatctcatc atcctgacga cgcggccgca
     3361 aagaagcagc aagaattacg agacgatctg gaactcgcag cgcaatgaga gcccgctgaa
     3421 gaccgtcacg cggtcgcagg cggagcaact tgccggctca attgtttccg gtgaattcgg
     3481 cgccggcgga gacatcgtcg tggactgggc gatgcgctac gccaatccgt cgatcctttc
     3541 gtccctgcaa cgcctgaggg agcagggatg cgggcgcgtg ctcatcgtcc cgctctatcc
     3601 gcaatttgcc ggcgcgacga ctttgagcgt cgccgacaag gtggaagagt cgctggcgcg
     3661 gatgaattgg cgtcctgaca tgcgcagcgt cccgccttat tataacgacc ctgtctacat
     3721 tgacgcgctg gcgcagtcgg ttcgcgcggg gctcgccgcg ctcgatttcg agcccgaagt
     3781 cgtcctcgtg tcgttccacg gcatcccgaa atcctatgtc gaggcgggcg atccttatta
     3841 cgaccaatgc gtcgagacct ggcggctgct gcgcgagcgc ctcgactttt cgcccgagcg
     3901 ctgtccgctc accttccagt cgcggttcgg gcgcgccgaa tggctttcgc cctacacgga
     3961 cgagactgtc aaggagctgg cgcgcaaggg cgtccggcgc atggcggtgc taacgccggg
     4021 cttttccgtc gattgcctcg agaccatctc cgagatcggc gtcgagaatc gcgagttctt
     4081 tatcgaggct ggcggcgagc aattcgcatt gatcccctgc ctcaatgaca gcgcgcttgg
     4141 gatgaaggtc atccgtcata tcgtctcgcg cgaactcgaa ggatggattt aggcacggct
     4201 tccggccggc tctgcgccga cgccggcgat gaggccgtcg gcgaaccagc gcgccaaaaa
     4261 ccccgcggcc tcgcccgcga cgtcttcgac gccgcgattt tgcgccagaa cggcgcagat
     4321 cagcccaaaa tcagccccgc gcatcaaggt ggccagggca agctcctcct cgccgccgag
     4381 cgcgcggtag aaagacagat cgcgctggcg ccagaacagc atcgtctcca tcggggaaga
     4441 ctcaaggtca ttcgcattcg cggcgtcggc cgcctcgatc ggctcgcttt ggctgagctc
     4501 ataagcgcgg cgcgcggcgt gcggcagcgc gatcatgcgc accgaagggt gcaaggcgaa
     4561 tgtcagctcc ggccattcct cgggggaatg cgctgcgaga acctcgatcg caagctgggg
     4621 cgcgtccggc gcgtcgaagg catgcgacaa agcgcgctcg aattcggcaa ggccgagggc
     4681 ctcgtcccgt tcgcgccaat cgggatcctc gcgcatgaaa tccggcagac cgcggcaata
     4741 atcctgcgcc gcgaaggcgc gcgaggggcg ctgttcgagg taggcttcaa acagcgcgcc
     4801 gaaggcctcg tcgccgagcc tttcgcgcaa ggcgggatat tcggcggaaa gacattccgc
     4861 cagccgcagc cgataggcgt ccgaatagat cttgaagcgc gccgccgcat tgagccttgg
     4921 cccgtcctcg acgcctgacg gggcggcctc gccgccggaa agaatggcgc tctgaaatag
     4981 gctctgcgat tgcttcagcg tcattcggca gcctgctttg cggacgccga cagggcgacg
     5041 gcccgcgcgc gatcgagttc ggcgacgagc tcctgaagcg gcgggaaatt gtcgtcgcgc
     5101 tcaatcatgg tcgagattgc gccaaagcgg cggcaggcgc gttcaaacaa agaccacacc
     5161 tcttcaatca ccggctggtc gtgggtgtcg atcttatgcg tctcatggtc cgaatgtccg
     5221 gcaaggtgaa actggagcac gcgctcttgc ggaatgtcgt cgagaaagcg ggccgggtcg
     5281 aagccatggt tgaagctcga gacgaagaca ttgttgacgt cgagaagcag ccagcaatcg
     5341 gctttttcgg cgagttcgcg caagaagacc tcttcggtca tctcggattc ggcgaaggtc
     5401 acatagctcg acacattttc gatggcgatg cggcgttgca gaaaatcctg aacgcgcaaa
     5461 atgcgctcgg cgacatgatg cagggcttcg cgcgtgtaag ggatcggcaa gaggtcgtgc
     5521 agattgacgc catggacgcc ggtccagcac aaatggtcgg aaatccattc cggctcgcag
     5581 cggcgggcga gatcccgcaa tttgccgaga tagtggaaat cgagcggcgc ggtcgatgcg
     5641 atcgacattg agacgccgtg catcacgatc gggtaattgg cgcgtatgtc gtcgaggatc
     5701 gccagcgggc gaccgccgcg gccaatgtaa ttttctgaaa tgatctcgaa ccagtcgatg
     5761 tcgggccgct gttcgatgat ttcggcatag tagcgatgcc ggaggccaag accgaagcca
     5821 agaggggcag gcttttgcat cgtcgctccc ggtatccgtc ggcgcatcgc acgaggcgcg
     5881 ggcggttcga tcacgccgcc gcgccccgca aagttgagcg gttatatcag ataaccgtgc
     5941 cgcctttcga cgtgcaggcg ctggttgact tcgccggcag ccagccatgg cccttgcagc
     6001 tgttttggcc cttgcaggcg ttttccgccg tcttgcaggc gcttgtgccc ttgcaggagt
     6061 tgatccccat gcaatgaacc gttttcgccg atttggcggc ggccgggctc aaggcggccc
     6121 cattcatcgc aagcgcgatg gcggcgatgg cgaggcttgc gccagaggcg actttgctgg
     6181 tccgaacgcc caaatcgtgg ctgctggtca tggttttctc cccagaaaaa cccgcggcgg
     6241 cgcgggcgtt gcgcgagccc ttgcggccca cacaagcttt acgcggggcg atgcggatgg
     6301 ttacgcgatc acgcgattgt gatcggttta cccggccttg cggttgtgca ggcggcgctc
     6361 ccaggacaga gcctgctcga cgatttcggc gagattgtcg tgtttcggcg tccagccgag
     6421 ctcctgcctg acgcggtcgg cgccggcgac cagcgaggcc ggatcgccgg gcctccgccc
     6481 cttcagccgc acctcgaaat cgacgcccga cactttcttt acaacctcga ccacttcgag
     6541 cacggatagt ccgcggccat agccgcaatt gcaggtgagg ctgccgccgc ccgcgcgcag
     6601 atgcgccagc gccagcaaat gtgcgtcgac gagatcggtc acctgaatgt agtcgcgcac
     6661 gcaggagccg tcgggcgtcg gataatcggt tccaaacacg tcaaggccgt cgcgatggcc
     6721 aagggcggcc tgcaccgcga ccttgatgag atgggtcgcg accggcgagg actggccgag
     6781 ccgcccggcg ggatcggctc cagcgacgtt gaaatagcgc aagaccacat agcgcagctg
     6841 atgcgccgcc gcgacgtcgg cgagcatcca ttcgaccatc agcttcgagc ggccataagg
     6901 gttgatcggc gcgagcgcga cattctcgaa gaccggattt tccgccggct cgccatagac
     6961 ggccgcggtc gaggagaaga tgaactgttt gacgccggcc ttgaccgcgc attcgagcag
     7021 gttgcgcgcc ttggcggtgt tgttgagata ataggcgagg gggtccgaga cggactccgg
     7081 gacgacgatc ttcgccgcga aatgggcgat cgcatcgatg cggtggtcgg cgaaaatctg
     7141 atcgacaagc gcgctgtcgc cgaagtctcc cacgatcagc ttggccgccg gcgggaccgc
     7201 ccaggcgaaa ccggtcgaga gattgtcaag gacgacgacc tcctcgccct gatcgagcag
     7261 cgccagcgcc atatggccgc cgatatagcc ggctcccccc gtaacgagca ccgtcatgaa
     7321 ttacccctct aagacgcagc cgccatttaa tgaatttgcc gcgaagtgga aatcatagtc
     7381 catcgtgata gcccggcgcc gtcgagcaag cttctccgcc gcctcatgac ggaattattg
     7441 cggaacttgt ggccgccccc aagctttagt cctgctcgat aatgcgcggc tcagccatac
     7501 gacataatgc tgcggttgcg ctcgctagtt tgacaggccg atcttggtta tgatcgcgcc
     7561 gccgttcatt cggcgccttt ccacgggacg gcgctcatct cagggacact cgatgacgaa
     7621 acggattcgc aaggctgttt ttccggtcgc gggcctcggc acgcggtttc ttccggcgac
     7681 caaatcgatc ccgaaggaaa tgttgacgat cgtcgatcgt cccgtgcttc agcatgtcgt
     7741 cgaggaggcg gccgaggccg gcatcgagca tttcatcttc gtcaccggac gcggcaaggc
     7801 ggtcatcgaa gatcatttcg acatcgccta tgagcttgac gacacgctgc agaaacgcgg
     7861 caagctgaaa gagttcaacg ccctcaagga gcaattgcca gccgccggcg cgacgagctt
     7921 tacgcgccag caggcgccgc tcggccttgg ccatgcgatc tggtgcgcgc gggagctcgt
     7981 cggcgacgag cctttcgccg tgctgctgcc cgacatggtg acgatggccg gcccgcagag
     8041 ttcaggccgc tgcctctccc aatgcattga agcctatgca aagcacggcg gcaacatcat
     8101 cgccgtcgag gaagtcgcgc cggaagagac gcaccaatat ggaatcgtat cgatcggcag
     8161 ggatttcggc tcatctttcg agattaccgg catggtggag aagccgccgc agggaaccgc
     8221 gccgtcgaac tgcatcattt ccggccgcta tctgctcggc ccggaaatct tcaagattct
     8281 ggaaaaggtc gagaagggcg caggcggcga gatccagctg accgacggca tgaaggagct
     8341 cgccgcgacg cagagctttc acggcgtgcg cttcgacggc aagacctatg attgcggctc
     8401 gaagctcggc tttctttcgg ccaatgtcgc cttcgcgctg tccaatcccg atatcgccgg
     8461 agccttcaag gccgaattga agaaattcgg gcctttctag cagtttcgcg aggccggcgg
     8521 cggccggcct cgccccgtct tacgcgtcgt cgagcgccgg atagtccgta tagccctcgg
     8581 ctgcgccgcc atagaaagtc tcgacatggg gagcattgag cggcgcattc tcgcgcagcc
     8641 gctcgacgag atcggggttg gagatgaaca atttgccgaa ggcgatcagg tcggcccgat
     8701 cggcttccag cgcctcgatc gcgaggtcgc gcgtataggc gttgttggcg atataggcgc
     8761 cgctgaagga tttgcgaaac gccggaaaat cgaatggcgc attatcccgc gcgccgcccg
     8821 tcgcgccttc gatcacgtgg atataggcga ggccgcgctg gctcagcgcc gcgacgagcg
     8881 ggaagaagac tttttcgggt gcgctgtcga ccgcgtcatt gacggggctg accggcgaga
     8941 gccggatccc gacgcgcgac ttgtcccaaa cggcaaggat cgcgtcggtg acttcgagcg
     9001 cgaaacgggt ccggttttct accgatccgc cataagaatc gtcgcgcttg ttggtcccgt
     9061 ccttcagaaa ctggtcgatc agatagccat tggcgccgtg gatctcgacg ccgtcgaagc
     9121 cggcgcgctt ggcgttctcg gcggcgcggc gatagtccgc gacgacgcgc gggatttcat
     9181 cgagggcgag cgcgcgcggc gccgagacgg gcgcgaggcc gctttcgata aaagtttggc
     9241 ccttcgccgc aatcgcggag ggggcgacgg gcgcgccgcc gcccggctgc agcgacacat
     9301 gcgagtaccg gccgacgtgc cagagctgga tgaaaatcag cccgccctcc tcatggacgg
     9361 cgtccgtcac ctttttccat ccctcgacct gctcctcgct ataaatgccg ggcgttgcga
     9421 aatagccttg gccttcctgc gaaatctgtg acgcctcgct gatgatcatg cccgcggaag
     9481 cgcgctggcg gtaatatgtc gcattgagat ccgagggggc cagcgtgccc ttcgtagcgc
     9541 ggctgcgtgt cagcggggcc atcacgatcc ggttcggcag gcgaaggtcg ccgagcgtga
     9601 aaggcgaaaa cagaacattg gcgtcagcgg tcatcgattg ctccaacttt cggtggcgaa
     9661 cgggggcgca ggatgactga aaacgcatga acgccccttg cgttgccgca aagcagcata
     9721 ggcgtccggc gtcggaaaaa ggtcctattt catgttgagc gcggacatat aaagttccag
     9781 gatcgcctcc atctccatcc gttcggcgtg atcctgcttg cgcagccgga cgatctggcg
     9841 gacgaccttg acgtcgaagc cgcgggcttt catctcggca tagacgtcgc ggatatcgtc
     9901 ggacaacgcc ttcttttctt cctcgagccg ctccacgcgc tcgacgaact gggtgagttc
     9961 ggcggcggcg acgccgcttt cggcgatatc tttcgtcatt ggcgaaggtc cttcaggatt
    10021 ggttctcgcg tccgccatgt ggcgttgcgg cgcgcgcgtc aaggcgcgag gcgcggtaat
    10081 ccccgctatt tgcgcttccg gctcacggcg tcgccctcag cgctccgcgt gccgccctgt
    10141 gcggctcggc aaaaaggcga gctgccgcaa ttccggcagc gccagcacgg atgcgaagat
    10201 cggcgcaagg cgatcggcgt agcgctccgc ctgctccttt gtcgaaatca gatcctggcg
    10261 aacctcgacg agcaacccgg cgaggccgcg ccgcgtcacc tcctcgtcca gcgtatcgcc
    10321 gacaagggcg ccgtcataag gctcattgtc gccgacgcaa aatcccgcct cgtcgagggc
    10381 tgcgatcagc ggcgcggcaa gacgcgcatc gctgtcccac agaattccga tctcccacgg
    10441 ccgcgttacg ccgcgccagc atggcgtgaa ggaatggatc gacaggacca cggggagggg
    10501 gccggcggct gtcatcatat cgaccgcaac cgagacggcg tcgcggtagg gacgccaata
    10561 gagcgcgatg cgccgttcga tttcctccgc ggcgatcgct gcattgcccg ggacaattgc
    10621 gccgtcggac agctgcatga ccagcgtcgg atcgtcgctg ccgcgattcg gatcgatcag
    10681 cagccgcgaa aaacgcgaca gaaccgccgg cgcgccgaac agcgaggcga ggcggagcgt
    10741 cagagcccgc gcgccaatat catagccgat atggcgttcg agctcgcttt gcggcaagcc
    10801 cagcgttcca taggggggcg gcagcgcgtt cgaggcgtga
//
